Semax
Also known as: Semax-Amidate, ACTH(4-10)
A synthetic heptapeptide that enhances cognitive function, stress resilience, and neuroprotection by modulating ACTH and endorphin pathways.
Beginner Basics
Plain-English guide to Semax
What it does
Semax is a short chain of amino acids that researchers study for supporting brain function, focus, and mental clarity. It's believed to work by influencing natural chemicals in your brain that affect mood and stress response.
Typical dose
Researchers commonly use 250-500 micrograms injected under the skin once or twice per day, starting at the lower dose to see how your body responds.
When to inject
Most researchers inject in the morning and/or early afternoon to take advantage of peak cognitive effects during the day.
Storage
Keep the powder in a cool, dry place away from light until you mix it. Once mixed with water, store it in the refrigerator and use within a few weeks.
First-timer tip
Start with the lowest dose (250 micrograms) in the morning for a few days before deciding to add a second dose-this lets you understand how your body responds without overwhelming it.
On This Page
Research Status
Clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Typically occurs within the first few injections and resolves spontaneously. May be related to initial HPA axis adjustment. Ensure adequate hydration and consider timing injection in the morning.
More likely if injected in the evening due to cognitive stimulation. Avoid afternoon/evening dosing if sensitive to stimulation. Morning injection typically resolves this issue.
May occur during initial titration as the HPA axis adjusts. Usually resolves within 3-5 days. Start at the lower dose (250 mcg) and titrate slowly.
Redness, mild itching, or soreness at the injection site. Prevent by rotating injection sites, allowing solution to reach room temperature, and using proper injection technique. Resolves within hours.
Slight increase or decrease in appetite reported in some users. Not clinically significant and typically transient.
Rare and typically mild. Ensure adequate hydration and food intake. Sit or lie down if symptoms occur.
Anaphylaxis or severe allergic response is extremely rare but possible in individuals with peptide sensitivity. Symptoms include difficulty breathing, swelling of face/throat, or severe rash. Seek immediate medical attention if these occur. Discontinue use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 250-500 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 813.9 g/mol |
| Half-life | 15-30 minutes (plasma); central nervous system effects persist 4-6 hours |
| Sequence | Members only |
Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment that enhances cognitive function and stress resilience by modulating the hypothalamic-pituitary-adrenal (HPA) axis and endogenous opioid pathways. It crosses the blood-brain barrier and acts as a neuroprotective agent, promoting neuroplasticity, reducing neuroinflammation, and enhancing memory consolidation through ACTH and endorphin receptor signaling. The peptide also exhibits anxiolytic properties and improves mental performance under stress.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Semax is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.