FGL
Also known as: FGL peptide, NCAM mimetic
Fibroblast Growth Factor-Like peptide, an NCAM (Neural Cell Adhesion Molecule) mimetic that enhances neural plasticity. Promotes learning, memory, and neuroprotection.
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Typically resolve within 24-48 hours. Rotate injection sites to minimize recurrence. Apply ice if swelling occurs. Ensure proper injection technique and sterile handling.
May occur in the first 1-2 weeks as the brain adjusts to enhanced neural signaling. Usually self-resolving. Stay hydrated and consider starting at a lower dose (1 mg) before titrating upward.
Enhanced neural activity may affect sleep in sensitive individuals. Consider injecting in the morning rather than evening. Typically resolves within 1-2 weeks as tolerance develops.
May occur if dose is too high or if injected too rapidly. Reduce dose and inject more slowly over 5 seconds. Ensure adequate hydration.
Uncommon with subcutaneous administration. If occurs, take with food or reduce dose. Discontinue if severe and consult a healthcare provider.
Develops with repeated injections in the same area. Prevent by rotating injection sites systematically with each dose. Maintain at least 1 inch spacing between injection points. Lipodystrophy may be reversible if site rotation is implemented early.
Discontinue immediately and seek medical attention if signs of allergic reaction develop (difficulty breathing, facial swelling, severe rash). FGL is a research compound with limited safety data in humans — monitor closely for any unusual reactions.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-5 mg |
| Frequency | 1x daily |
| Timing | Any time of day |
| Route | Subcutaneous |
Research compound with limited human dosing data. Start at 1 mg and titrate based on tolerance and response. Subcutaneous injection preferred. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
FGL is a synthetic peptide that mimics Neural Cell Adhesion Molecule (NCAM) and activates fibroblast growth factor receptors (FGFR) in the brain. This activation promotes synaptic plasticity, enhances long-term potentiation (LTP), and supports neuronal survival and growth. By mimicking NCAM signaling, FGL enhances learning and memory formation while providing neuroprotection against excitotoxic and inflammatory damage.
NCAM-FGFR Signaling
FGL binds to and activates fibroblast growth factor receptors (FGFR1 and FGFR3) on neuronal surfaces, mimicking the natural NCAM-FGF interaction. This triggers downstream signaling cascades that enhance synaptic plasticity, increase dendritic spine density, and promote long-term potentiation (LTP) — the cellular basis of learning and memory.
Neuroprotection via PI3K/Akt Pathway
FGFR activation by FGL stimulates the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt) signaling cascade, which suppresses pro-apoptotic factors and enhances neuronal survival. This pathway protects neurons from excitotoxicity, oxidative stress, and neuroinflammation.
Synaptic Plasticity Enhancement
FGL promotes the expression of neurotrophic factors (including BDNF) and enhances AMPA and NMDA receptor trafficking at synapses. This increases synaptic strength and facilitates the formation of new neural connections, supporting learning and memory consolidation.
- FGL is an NCAM-derived peptide that activates FGFR signaling in the central nervous system
- Enhances synaptic plasticity and long-term potentiation (LTP), the cellular mechanism of learning and memory
- Provides neuroprotection by suppressing apoptosis and reducing neuroinflammation
- Promotes neuronal survival and growth through multiple signaling pathways (PI3K/Akt, MAPK/ERK)
- Research suggests potential applications in cognitive enhancement, neuroprotection, and neurodegenerative disease prevention
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. FGL is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.