Research Use Only - Not for human consumption. 18+ only.
Clinical TrialsCognitive EnhancementSubcutaneousIntranasal

Dihexa

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

Dihexa is an oligopeptide drug with remarkable cognitive enhancement properties. It is 7 orders of magnitude more potent than BDNF and shows promise for neurodegenerative diseases.

Research Status

Clinical Trials

Research compound - Phase 1 clinical trials

For research purposes only. Not approved for human use. Not medical advice.

Research Areas

Dramatically improves cognitive function
Promotes neurogenesis
Enhances memory formation
May reverse cognitive decline
Increases synaptic connections
Potential for Alzheimer's treatment

Side Effects

Headache
UncommonMild

May occur early in treatment or with dose escalation. Usually resolves within hours. Ensure adequate hydration and consider taking at a time when you can rest if needed. If persistent, reduce dose and titrate more slowly.

Insomnia or Sleep Disturbance
UncommonMild

Dihexa's cognitive stimulation may cause wakefulness if injected too late in the day. Inject in the morning (6-8 AM) to minimize this effect. Avoid injecting within 8 hours of bedtime.

Anxiety or Nervousness
UncommonMild

May occur with higher doses or rapid dose escalation. Start with the lowest dose (0.25-0.5mg) and increase gradually over 2-4 weeks. Reduce dose if anxiety develops.

Dizziness or Lightheadedness
RareMild

May occur immediately after injection. Sit or lie down for 5-10 minutes after injection if this occurs. Ensure adequate hydration and food intake.

Injection Site Reactions
UncommonMild

Mild redness, itching, or swelling at the injection site. Rotate injection sites to prevent lipodystrophy and localized reactions. Use proper injection technique and sterile supplies.

Appetite Changes
UncommonMild

Some users report increased or decreased appetite. Monitor food intake and adjust diet as needed. Ensure adequate nutrition to support neuronal health.

Mood Elevation or Euphoria
UncommonMild

Some users report elevated mood or mild euphoria, particularly at higher doses. This is generally self-resolving but may warrant dose reduction if excessive.

Tremor or Jitteriness
RareMild

May occur with high doses. Reduce dose and titrate more slowly. Ensure adequate sleep and minimize caffeine intake.

Nausea
RareMild

Uncommon but may occur with rapid dose escalation or on an empty stomach. Take with food or reduce dose. Ensure proper reconstitution and sterile technique.

Dosing Reference

ParameterValue
Dose range0.25-2 mg
FrequencyDaily or every other day
TimingMorning
RouteSubcutaneous, Intranasal

Start with lowest dose. Effects are cumulative. Extremely potent.

Research disclaimer

Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.

Reconstitution Guide

Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution

Do not shake the vial vigorously; gentle swirling prevents peptide degradation

Discard immediately if the solution appears cloudy, discolored, or contains visible particles

Use within 30 days of reconstitution when stored at 2–8°C

Do not freeze the reconstituted solution; freezing may denature the peptide

Use the PeptideVolt reconstitution calculator for your exact concentration

Use the PeptideVolt reconstitution calculator for your exact concentration

Molecular and Pharmacological Data

Dihexa is a synthetic hexapeptide that acts as a potent brain-derived neurotrophic factor (BDNF) mimetic, demonstrating approximately 7 orders of magnitude greater potency than native BDNF. It crosses the blood-brain barrier and binds to TrkB receptors on neurons, activating signaling cascades that promote neuronal survival, growth, and synaptic plasticity. This mechanism underlies its cognitive enhancement and neuroprotective properties, making it of interest for neurodegenerative disease research.

TrkB Receptor Activation

Dihexa binds to tropomyosin receptor kinase B (TrkB) receptors on neuronal cell surfaces, triggering autophosphorylation and downstream signaling cascades (PI3K/Akt, MAPK/ERK) that promote neuronal survival and differentiation

Synaptic Plasticity

TrkB activation enhances long-term potentiation (LTP) and long-term depression (LTD), cellular mechanisms underlying learning and memory formation

Neurogenesis

Dihexa promotes proliferation and differentiation of neural progenitor cells in the hippocampus and other brain regions, supporting cognitive function

Neuroprotection

TrkB signaling activates anti-apoptotic pathways and reduces oxidative stress, protecting neurons from degeneration and age-related decline

  • Dihexa is approximately 7 orders of magnitude (10,000,000×) more potent than native BDNF in vitro
  • It crosses the blood-brain barrier, allowing direct access to central nervous system targets
  • Effects are cumulative; cognitive benefits may increase with continued use over weeks to months
  • Research suggests efficacy in animal models of cognitive decline, Alzheimer's disease, and traumatic brain injury
  • The peptide's extreme potency necessitates precise dosing and careful titration to avoid adverse effects

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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Dihexa is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.