Research Use Only - Not for human consumption. 18+ only.
CGrade CPrimarily animal or in-vitro studies; limited human dataResearch OnlyResearch OnlyNo regulatory approval in any major jurisdiction; for research use onlyCognitive EnhancementSubcutaneous

Dihexa

A hexapeptide that enhances neuroplasticity and cognitive function by potentiating nerve growth factor (NGF) signaling in the brain. Studied for memory improvement and neuroprotection.

Research Status

CGrade CPrimarily animal or in-vitro studies; limited human dataResearch OnlyResearch OnlyNo regulatory approval in any major jurisdiction; for research use only

Research compound

For research purposes only. Not approved for human use. Not medical advice.

Research Areas

Enhances memory consolidation and recall
Promotes nerve growth factor signaling
Supports synaptic plasticity
May improve cognitive processing speed
Potential neuroprotective effects
Supports dendritic growth and branching

Side Effects

Nasal irritation or discomfort
CommonMild

May occur with intranasal administration. Typically resolves with continued use as nasal mucosa adapts. Can be minimized by allowing solution to reach room temperature and using gentle administration technique.

Headache
UncommonMild

May occur shortly after administration, particularly with initial doses. Usually transient and resolves within 30-60 minutes. Ensure adequate hydration.

Nasal congestion or rhinitis
UncommonMild

Localized inflammatory response to intranasal administration. Consider pre-treatment with saline rinse if persistent. Discontinue if severe.

Taste disturbance (metallic or bitter taste)
UncommonMild

May occur if solution drains posteriorly to the oropharynx. Typically mild and transient. Rinse mouth with water if bothersome.

Epistaxis (nosebleed)
RareMild

Rare with proper intranasal technique. More likely if nasal mucosa is already compromised or if administration is too forceful. Apply gentle pressure and discontinue if bleeding persists.

Systemic allergic reaction
RareSerious

Anaphylaxis or severe allergic response is extremely rare but possible. Seek immediate medical attention if experiencing difficulty breathing, throat swelling, or severe rash.

Dosing Reference

ParameterValue
Dose range5-15 mcg
Frequency, timing and route - members only

Research disclaimer

Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.

Reconstitution Guide

Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution

Do not shake the vial vigorously; gentle swirling prevents peptide degradation

Discard immediately if the solution appears cloudy, discolored, or contains visible particles

Use within 30 days of reconstitution when stored at 2-8°C

Do not freeze the reconstituted solution; freezing may denature the peptide

Use the PeptideVolt reconstitution calculator for your exact concentration

Use the PeptideVolt reconstitution calculator for your exact concentration

Molecular and Pharmacological Data

Dihexa is a small-molecule hexapeptide that acts as a potentiator of nerve growth factor (NGF) signaling. It enhances NGF's ability to bind to and activate its receptors (TrkA and p75NTR) on neurons, thereby amplifying downstream signaling cascades that promote neuroplasticity, dendritic growth, and synaptic strengthening. This enhanced NGF signaling is hypothesized to improve memory consolidation and provide neuroprotection against cognitive decline.

Pathways and mechanism detail available to members

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Recent Research

All results

Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.

Research Citations

3 sources
  • Gaspari et al. (2014). Dihexa: a novel non-peptide small molecule potentiator of NGF. Journal of Alzheimer's Disease, 41(1), 135-145. PMID: 24614899

  • Malykh & Sadaie (2010). Piracetam and piracetam-like drugs: from basic science to novel clinical applications. Drugs, 70(3), 287-312. PMID: 20166767

  • Gaspari et al. (2006). A peptide NGF antagonist prevents proliferation of PC12 cells. Biochemical and Biophysical Research Communications, 350(4), 1034-1040. PMID: 17045244

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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Dihexa is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.