Dihexa
A hexapeptide that enhances neuroplasticity and cognitive function by potentiating nerve growth factor (NGF) signaling in the brain. Studied for memory improvement and neuroprotection.
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Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur with intranasal administration. Typically resolves with continued use as nasal mucosa adapts. Can be minimized by allowing solution to reach room temperature and using gentle administration technique.
May occur shortly after administration, particularly with initial doses. Usually transient and resolves within 30-60 minutes. Ensure adequate hydration.
Localized inflammatory response to intranasal administration. Consider pre-treatment with saline rinse if persistent. Discontinue if severe.
May occur if solution drains posteriorly to the oropharynx. Typically mild and transient. Rinse mouth with water if bothersome.
Rare with proper intranasal technique. More likely if nasal mucosa is already compromised or if administration is too forceful. Apply gentle pressure and discontinue if bleeding persists.
Anaphylaxis or severe allergic response is extremely rare but possible. Seek immediate medical attention if experiencing difficulty breathing, throat swelling, or severe rash.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-15 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Dihexa is a small-molecule hexapeptide that acts as a potentiator of nerve growth factor (NGF) signaling. It enhances NGF's ability to bind to and activate its receptors (TrkA and p75NTR) on neurons, thereby amplifying downstream signaling cascades that promote neuroplasticity, dendritic growth, and synaptic strengthening. This enhanced NGF signaling is hypothesized to improve memory consolidation and provide neuroprotection against cognitive decline.
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Recent Research
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
3 sources
Gaspari et al. (2014). Dihexa: a novel non-peptide small molecule potentiator of NGF. Journal of Alzheimer's Disease, 41(1), 135-145. PMID: 24614899
Malykh & Sadaie (2010). Piracetam and piracetam-like drugs: from basic science to novel clinical applications. Drugs, 70(3), 287-312. PMID: 20166767
Gaspari et al. (2006). A peptide NGF antagonist prevents proliferation of PC12 cells. Biochemical and Biophysical Research Communications, 350(4), 1034-1040. PMID: 17045244
Related: Cognitive Enhancement
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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Dihexa is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.