Selank
Also known as: NA-Selank
Selank is a synthetic anxiolytic peptide based on tuftsin, a naturally occurring immunomodulatory peptide. It has nootropic and anxiolytic properties without causing sedation or dependency. Developed in Russia.
Research Status
Approved in Russia for anxiety disorders
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in the first few days of use. Usually resolves without intervention. Ensure adequate hydration and consider taking at a different time of day if persistent.
More common with intranasal administration. Typically transient. Sit or lie down if experienced; symptoms usually resolve within 15-30 minutes.
May include mild nasal congestion, sneezing, or throat irritation. Use a saline rinse after administration if irritation occurs. Consider rotating between intranasal and subcutaneous routes.
Mild redness, itching, or slight swelling at injection site. Usually resolves within 1-2 hours. Ensure proper site rotation to minimize recurrence.
More likely if Selank is administered late in the day. Administer in the morning or early afternoon. If persistent, consult a healthcare provider.
Occasionally reported. Monitor dietary intake if this occurs.
Symptoms may include rash, urticaria, difficulty breathing, or angioedema. Seek immediate medical attention if any signs of anaphylaxis occur. Discontinue use and consult a healthcare provider.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 250-500 mcg |
| Frequency | 1-3x daily |
| Timing | Morning and throughout day as needed |
| Route | Intranasal, Subcutaneous |
Intranasal spray or subcutaneous. Can be used daily or as needed. Cycle 2-4 weeks.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 823 |
| Half-life | 4-6 hours (intranasal); approximately 6-8 hours (subcutaneous) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
Selank is a synthetic heptapeptide derived from tuftsin that acts as an anxiolytic and nootropic agent by modulating neurotransmitter systems and enhancing immune function. It increases dopamine and serotonin levels in the brain while reducing anxiety without causing sedation or cognitive impairment. The peptide also exhibits immunomodulatory properties, enhancing immune cell activity and promoting neuroprotection through multiple signaling pathways.
Monoamine Neurotransmitter Modulation
Selank increases dopamine and serotonin availability in the prefrontal cortex and limbic system, improving mood regulation and reducing anxiety symptoms without the sedative effects of traditional anxiolytics.
Immune Modulation via Tuftsin Pathway
As a tuftsin derivative, Selank enhances phagocytic activity of macrophages and neutrophils, supporting immune function and potentially contributing to neuroprotection through immune-mediated mechanisms.
Neuropeptide Y (NPY) System
Selank may interact with NPY signaling, which is involved in anxiety regulation, stress response, and cognitive function, contributing to its anxiolytic and nootropic effects.
GABA and Glutamate Balance
Evidence suggests Selank modulates inhibitory and excitatory neurotransmission, promoting a balanced neurochemical state that reduces anxiety while maintaining cognitive clarity.
- Selank is non-sedating, unlike benzodiazepines and other traditional anxiolytics, making it suitable for daytime use
- No dependency or tolerance development has been documented in clinical studies, even with prolonged use
- The peptide crosses the blood-brain barrier effectively via both intranasal and subcutaneous routes
- Anxiolytic effects typically emerge within 30-60 minutes of intranasal administration and 1-2 hours of subcutaneous injection
- Selank exhibits a favorable safety profile with minimal adverse effects in clinical research
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