Noopept
Also known as: GVS-111, Noopeptide
A potent nootropic peptide that enhances memory, learning, and cognitive function. Increases NGF and BDNF expression. Significantly more potent than piracetam on a per-milligram basis.
Beginner Basics
Plain-English guide to Noopept
What it does
This peptide is used by researchers to study how to improve memory, learning, and thinking speed. It works by triggering the brain to produce more growth factors that help brain cells stay healthy and form new connections.
Typical dose
Researchers typically use 10-30 mg taken once or twice daily, either swallowed or dissolved under the tongue.
When to inject
Take it in the morning or early afternoon to avoid interfering with sleep; most researchers avoid using it in the evening.
Storage
Keep the dry powder in a freezer at -20°C (around -4°F). Once mixed with liquid, store it in a regular refrigerator (2-8°C or 35-46°F) and keep it away from light.
First-timer tip
Start with the lowest dose (10 mg) for a few days to see how your body responds before increasing to higher amounts.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur during the first few days of use. Usually resolves with continued use or dose reduction. Ensure adequate hydration.
Some users report mild irritability or emotional sensitivity, particularly at higher doses. Typically resolves within 1-2 weeks. Consider dose reduction if persistent.
Noopept has mild stimulant properties. Avoid dosing in the late afternoon or evening. Take morning dose only if sleep disruption occurs.
Nausea or mild GI upset reported in <1% of users. Take with food if this occurs. Sublingual administration may reduce GI effects.
Rare at therapeutic doses. May occur at doses >30 mg daily. Reduce dose if this develops.
Rash, itching, swelling of face/throat, or difficulty breathing require immediate medical attention. Discontinue use and seek emergency care.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 10-30 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 318.35 |
| Half-life | 0.3-0.5 hours (plasma); CNS effects persist 8-12 hours |
| Sequence | Members only |
Noopept is a cyclic dipeptide that crosses the blood-brain barrier and enhances cognitive function primarily through upregulation of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). These neurotrophic factors promote neuroplasticity, synaptic transmission, and neuroprotection. The peptide is approximately 1000-fold more potent than piracetam on a per-milligram basis and may also modulate ion channel activity and reduce neuroinflammation.
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Recent Research
A Mini-Review on Unlocking Cognitive Enhancement: An Innovative Strategy for Optimal Brain Functions.
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories.
Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Noopept is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.