Noopept
Also known as: GVS-111, Noopeptide
A potent nootropic peptide that enhances memory, learning, and cognitive function. Increases NGF and BDNF expression. Significantly more potent than piracetam on a per-milligram basis.
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur during the first few days of use. Usually resolves with continued use or dose reduction. Ensure adequate hydration.
Some users report mild irritability or emotional sensitivity, particularly at higher doses. Typically resolves within 1-2 weeks. Consider dose reduction if persistent.
Noopept has mild stimulant properties. Avoid dosing in the late afternoon or evening. Take morning dose only if sleep disruption occurs.
Nausea or mild GI upset reported in <1% of users. Take with food if this occurs. Sublingual administration may reduce GI effects.
Rare at therapeutic doses. May occur at doses >30 mg daily. Reduce dose if this develops.
Rash, itching, swelling of face/throat, or difficulty breathing require immediate medical attention. Discontinue use and seek emergency care.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 10-30 mg |
| Frequency | 1-2x daily |
| Timing | Morning and/or early afternoon to avoid evening stimulation |
| Route | Subcutaneous |
Oral or sublingual administration. Approved in Russia and some Eastern European countries as a nootropic medication. Start at 10 mg daily and assess tolerance before increasing. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 318.35 |
| Half-life | 0.3-0.5 hours (plasma); CNS effects persist 8-12 hours |
| Sequence | N-phenylacetyl-L-prolyl-glycine ethyl ester |
Noopept is a cyclic dipeptide that crosses the blood-brain barrier and enhances cognitive function primarily through upregulation of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). These neurotrophic factors promote neuroplasticity, synaptic transmission, and neuroprotection. The peptide is approximately 1000-fold more potent than piracetam on a per-milligram basis and may also modulate ion channel activity and reduce neuroinflammation.
NGF/BDNF Signaling
Noopept increases expression of nerve growth factor and brain-derived neurotrophic factor, which promote neuronal survival, growth, and synaptic plasticity. These factors are critical for memory formation and learning.
Neuroprotection
The peptide exhibits antioxidant and anti-inflammatory properties in the brain, reducing oxidative stress and neuroinflammation that can impair cognitive function.
Synaptic Transmission
Noopept enhances the efficiency of neurotransmitter release and receptor sensitivity, improving communication between neurons and supporting faster cognitive processing.
Ion Channel Modulation
The peptide may modulate voltage-gated ion channels, affecting neuronal excitability and membrane potential in ways that support cognitive enhancement.
- Noopept crosses the blood-brain barrier efficiently due to its lipophilic structure
- NGF and BDNF upregulation is dose-dependent and occurs within hours of administration
- The peptide does not directly activate GABA or glutamate receptors, distinguishing it from classical GABAergics
- Cognitive benefits accumulate over 2-4 weeks of consistent use; acute effects are modest
- Animal studies show neuroprotection against ischemia, excitotoxicity, and age-related cognitive decline
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Noopept is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.