What is the typical dose of Lysine-Arginine?

Typical research doses are 500-1000 mcg, administered 1-2x daily. Commonly timed: Post-exercise or before bed. These are research figures only — not clinical recommendations.

What are the known side effects of Lysine-Arginine?

Side effects reported in research include: Gastrointestinal discomfort (uncommon, mild); Headache (uncommon, mild); Flushing or skin redness (uncommon, mild); Dizziness or lightheadedness (rare, mild); Local injection site reactions (uncommon, mild); Allergic reaction (rare, serious). Always consult a qualified professional before use.

How is Lysine-Arginine administered?

Lysine-Arginine is typically administered via Subcutaneous.

Can Lysine-Arginine be injected?

In the research literature, Lysine-Arginine is described with subcutaneous administration. This is research information only, not medical advice.

What is the evidence quality for Lysine-Arginine?

Lysine-Arginine carries an evidence grade of C. Grade C — supported by animal studies or in-vitro research.

Muscle Growth & Performance / Subcutaneous

Lysine-Arginine

Q: What is Lysine-Arginine used for in research?

Research on Lysine-Arginine has focused on: Enhances nitric oxide production; Improves blood flow and vasodilation; Supports muscle nutrient delivery; May improve exercise performance; Supports cardiovascular function.

A dipeptide combination that enhances nitric oxide production and vasodilation, improving blood flow and nutrient delivery to muscles.

What is Lysine-Arginine used for? Research has focused on enhances nitric oxide production; improves blood flow and vasodilation; supports muscle nutrient delivery.

Compare with other peptides studied formuscle growth

Evidence grade CResearch only

Lysine-Arginine injection at a glance

Figures from the published research literature. Research use only.

Dose range: 500-1000 mcg
Route: Subcutaneous

How often, when, and the dosing notes are in the dosing reference further down.

Work out your units in the free calculator

Research status

Evidence grade C: Mostly animal or in-vitro studies, with limited human data.
Research only: No regulatory approval in any major jurisdiction. Research use only.

Research compound

For research purposes only. Not approved for human use. Not medical advice.

Research areas

Enhances nitric oxide production
Improves blood flow and vasodilation
Supports muscle nutrient delivery
May improve exercise performance
Supports cardiovascular function

Side effects

Effect	How often	Severity
Gastrointestinal discomfortMay occur with higher doses or in sensitive individuals. Typically resolves with dose reduction or taking with food. Nausea or mild stomach upset reported in some users.	Uncommon	Mild
HeadacheMay be related to rapid vasodilation or changes in blood pressure. Usually mild and transient. Ensure adequate hydration.	Uncommon	Mild
Flushing or skin rednessRelated to vasodilation effects. Typically mild and temporary, resolving within minutes to hours.	Uncommon	Mild
Dizziness or lightheadednessMay occur due to blood pressure changes from vasodilation. Sit or lie down if experienced. Ensure adequate hydration and electrolyte balance.	Rare	Mild
Local injection site reactionsMild redness, itching, or slight swelling at injection site. Typically resolves within hours. Rotate injection sites to minimize.	Uncommon	Mild
Allergic reactionSeek immediate medical attention if experiencing rash, difficulty breathing, or swelling of face/throat. Discontinue use immediately.	Rare	Serious

Dosing reference

Dose scale from the research

Starting: 500 mcg
Typical: 750 mcg
Upper end: 1000 mcg

Lysine-Arginine dosing reference
Parameter	Value
Dose range	500-1000 mcg
Frequency, timing and route are for members Sign up free Log in

Checked October 2026

Research disclaimer. Figures are drawn from published research literature and community logs. They are not clinical recommendations. Consult a qualified professional. Research use only.

Reconstitution guide

Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration

Worked example

With 5 mg in the vial, the water you add changes the draw. Mixed with 1 mL that is 5,000 mcg per mL, so on a U-100 syringe 500 mcg is 10 units and 1000 mcg is 20 units. Mixed with 2 mL it is 2,500 mcg per mL, so 500 mcg is 20 units and 1000 mcg is 40 units.

Work out your exact dose in the free peptide calculator

Molecular and pharmacological data

Lysine-Arginine is a dipeptide combination that works synergistically to enhance nitric oxide (NO) production in endothelial cells. Arginine serves as the substrate for nitric oxide synthase (NOS), the enzyme responsible for NO synthesis, while lysine may enhance arginine bioavailability and uptake. Increased nitric oxide promotes vasodilation, improves blood flow, and enhances nutrient and oxygen delivery to muscle tissue, potentially supporting exercise performance and recovery.

Pathways and mechanism detail are for members

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Recent research

All results on PubMed

Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.

Research citations

4 sources

Cormio L, De Siati M, Lorusso F, et al. (2011). Oral L-arginine supplementation improves in vitro fertilization outcome in male factor infertility: a prospective, randomized, placebo-controlled clinical trial. Fertil Steril. 96(6):1488-1493. PMID: 21993613
Stanislavov R, Nikolova V. (2003). Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 29(3):207-213. PMID: 12851125
Cormio L, De Siati M, Lorusso F, et al. (2011). Oral L-arginine supplementation improves in vitro fertilization outcome in male factor infertility. Fertil Steril. 96(6):1488-1493.
Böger RH. (2007). The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res. 73(2):290-297. PMID: 16973416

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Research use only. All content on this page is provided for informational and educational purposes related to scientific research. Lysine-Arginine is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.