Lysine-Arginine
A dipeptide combination that enhances nitric oxide production and vasodilation, improving blood flow and nutrient delivery to muscles.
On This Page
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur with higher doses or in sensitive individuals. Typically resolves with dose reduction or taking with food. Nausea or mild stomach upset reported in some users.
May be related to rapid vasodilation or changes in blood pressure. Usually mild and transient. Ensure adequate hydration.
Related to vasodilation effects. Typically mild and temporary, resolving within minutes to hours.
May occur due to blood pressure changes from vasodilation. Sit or lie down if experienced. Ensure adequate hydration and electrolyte balance.
Mild redness, itching, or slight swelling at injection site. Typically resolves within hours. Rotate injection sites to minimize.
Seek immediate medical attention if experiencing rash, difficulty breathing, or swelling of face/throat. Discontinue use immediately.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 500-1000 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Lysine-Arginine is a dipeptide combination that works synergistically to enhance nitric oxide (NO) production in endothelial cells. Arginine serves as the substrate for nitric oxide synthase (NOS), the enzyme responsible for NO synthesis, while lysine may enhance arginine bioavailability and uptake. Increased nitric oxide promotes vasodilation, improves blood flow, and enhances nutrient and oxygen delivery to muscle tissue, potentially supporting exercise performance and recovery.
Track your Lysine-Arginine research
Free account. No credit card required.
Recent Research
Effects of phenylalanine supplementation on meat fatty acid composition, gut microbiota, and pork volatile organic compound profile in finishing pigs.
Sodium arsenite inhibits ALKBH7 increasing tRNA m(2)(2)G methylation in mitochondrial respiratory chain complex-flankng to drive malignant phenotype of bladder epithelial cells.
Integrating mass spectrometry imaging and data-driven segmentation for spatial metabolic mapping of diabetic eye disease.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
4 sources
Cormio L, De Siati M, Lorusso F, et al. (2011). Oral L-arginine supplementation improves in vitro fertilization outcome in male factor infertility: a prospective, randomized, placebo-controlled clinical trial. Fertil Steril. 96(6):1488-1493. PMID: 21993613
Stanislavov R, Nikolova V. (2003). Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 29(3):207-213. PMID: 12851125
Cormio L, De Siati M, Lorusso F, et al. (2011). Oral L-arginine supplementation improves in vitro fertilization outcome in male factor infertility. Fertil Steril. 96(6):1488-1493.
Böger RH. (2007). The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res. 73(2):290-297. PMID: 16973416
Related: Muscle Growth & Performance
Browse the Research Library
133 peptide profiles and 54 blend profiles with mechanism summaries, dosing data, and reconstitution guides.
View all peptidesStay updated on Lysine-Arginine research
Weekly digest of new peptide research, stack guides, and platform updates.
Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Lysine-Arginine is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.