MGF
Also known as: MGF (Mechano Growth Factor), IGF-1 Ec
Mechano Growth Factor, a splice variant of IGF-1 produced in response to mechanical stress on muscle tissue. Promotes localized muscle repair and growth at the injection site.
Research Status
Limited Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Typically resolves within minutes to hours. Minimize by allowing the solution to reach room temperature before injection and using proper injection technique. Apply ice if needed.
May occur within hours of injection and typically resolves within 24-48 hours. Related to the inflammatory response and growth factor activity. Apply ice if uncomfortable.
May appear at the injection site due to increased blood flow and local inflammation. Usually resolves within 24 hours. Avoid rubbing the area.
IGF-1 variants can enhance insulin sensitivity and glucose uptake. Monitor blood glucose if diabetic or pre-diabetic. Consume carbohydrates if symptoms of hypoglycemia occur (shakiness, sweating, confusion).
Repeated injections in the same site can cause localized fat loss (lipoatrophy) or rarely fat accumulation (lipohypertrophy). Prevent by rotating injection sites with each dose and maintaining at least 1 inch between injection points.
Occasionally reported with peptide use. Usually mild and self-resolving. Stay hydrated and monitor frequency.
May occur immediately after injection. Sit or lie down if this occurs. Typically resolves within minutes.
Occasionally reported. Usually mild and transient. Ensure adequate hydration and food intake around injection time.
Symptoms may include localized itching, hives, swelling of lips/throat, or difficulty breathing. Seek immediate medical attention if systemic symptoms occur. Discontinue use if allergic reaction is suspected.
Risk minimized by using sterile technique, clean needles, and proper site rotation. Signs include increasing redness, warmth, pus, or fever. Seek medical attention if infection is suspected.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 100-200 mcg |
| Frequency | 1x daily |
| Timing | Post-workout, within 30-60 minutes of training session |
| Route | Subcutaneous |
Inject near target muscle that was trained. Short half-life (2-3 hours) requires localized injection for efficacy. Start at 100 mcg and assess response before increasing. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Half-life | 2-3 hours (localized tissue half-life; shorter than systemic IGF-1) |
| Sequence | MGFPLDLKGC-IGF-1 (N-terminal E peptide of IGF-1 Ec isoform) |
MGF (Mechano Growth Factor) is an N-terminal splice variant of IGF-1 produced locally in muscle tissue in response to mechanical stress and exercise. Unlike systemic IGF-1, MGF acts primarily through paracrine signaling to activate muscle satellite cells, promote myoblast proliferation and differentiation, and enhance localized muscle protein synthesis. This localized mechanism makes MGF particularly effective for post-workout muscle repair and hypertrophy when injected near the trained muscle.
IGF-1 Receptor (IGF-1R) Signaling
MGF binds to IGF-1 receptors on muscle satellite cells and myoblasts, activating the PI3K/Akt and MAPK/ERK pathways, which promote protein synthesis, cell survival, and differentiation into mature muscle fibers.
Satellite Cell Activation
MGF specifically stimulates quiescent satellite cells to enter the cell cycle and proliferate, providing myonuclei for muscle fiber growth and repair. This is a key mechanism distinct from systemic IGF-1.
Muscle Protein Synthesis
Through IGF-1R activation, MGF increases mTOR signaling and ribosomal protein synthesis, enhancing the anabolic response to resistance training.
Myogenic Differentiation
MGF promotes the differentiation of activated myoblasts into mature myocytes, facilitating muscle fiber growth and repair after mechanical damage.
- MGF is produced endogenously in response to mechanical loading and muscle damage, making it a natural adaptation signal
- MGF has superior effects on satellite cell activation compared to mature IGF-1, making it more effective for muscle repair
- The short half-life of MGF (2-3 hours) necessitates localized injection near the target muscle for efficacy
- MGF acts primarily through paracrine signaling in muscle tissue rather than systemic endocrine effects
- Post-workout injection timing capitalizes on the natural upregulation of growth factor signaling during the muscle repair window
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. MGF is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.