ACE-031
A soluble activin receptor type IIB (ActRIIB) fusion protein that functions as a myostatin and activin A trap. Developed for treatment of muscle wasting diseases, including muscular dystrophy and cachexia. Acts by sequestering myostatin and activin A, negative regulators of muscle growth.
Beginner Basics
Plain-English guide to ACE-031
What it does
ACE-031 blocks two chemicals that limit muscle growth, allowing muscles to build larger and stronger. Researchers studied it for conditions where muscles waste away, but development was paused due to safety concerns.
Typical dose
Research doses ranged from 1-3 mg per kilogram of body weight, given every two weeks through injection into a vein or under the skin.
When to inject
In research settings, timing was flexible since it was given every two weeks. Healthcare providers supervised all administration.
Storage
Keep the dry powder in a freezer at -20°C. Once mixed with liquid, store in a regular refrigerator at 36-46°F for up to 14 days. Keep it away from light and throw it away if it looks cloudy or discolored.
First-timer tip
This compound is not approved for human use outside controlled research-it was halted in development due to safety signals. Do not use without medical supervision in an official trial.
On This Page
Research Status
Limited Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Observed in clinical trials. Likely due to activin A inhibition, which normally suppresses hepcidin and iron metabolism. Requires regular hematologic monitoring. May increase thrombotic risk if severe.
Observed in animal studies at high doses. Manifested as sensory neuropathy and neuronal degeneration. Human incidence unclear; clinical trials were paused partly due to this signal. Requires neurological assessment if symptoms develop.
Erythema, induration, or mild pain at injection site. Typical of SC protein therapeutics. Rotate injection sites to minimize.
Reported in clinical trials. Usually self-resolving. Monitor frequency and severity.
Reported in some trial participants. May be related to systemic effects of myostatin/activin inhibition or polycythemia.
Anecdotally reported in trials. Mechanism unclear; may relate to altered TGF-β signaling in connective tissue.
Isolated cases reported in clinical trials. Polycythemia and altered hemodynamics may increase thrombotic or ischemic risk. Requires baseline and periodic cardiovascular assessment.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-3 mg/kg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 110 kDa (approximately) |
| Half-life | 3-5 days (estimated from preclinical data; human half-life not definitively established due to trial discontinuation) |
ACE-031 is a soluble ActRIIB receptor ectodomain that acts as a ligand trap, binding and sequestering myostatin and activin A—two TGF-β superfamily members that negatively regulate muscle growth. By removing these inhibitory signals, ACE-031 permits increased muscle protein synthesis and hypertrophy, particularly in conditions characterized by elevated myostatin or activin A signaling.
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