Kisspeptin-10
Also known as: Metastin, KP-10
Kisspeptin-10 is a neuropeptide that regulates reproductive hormone secretion. It stimulates GnRH, leading to LH and FSH release, and may enhance libido and sexual function.
Beginner Basics
Plain-English guide to Kisspeptin-10
What it does
Kisspeptin-10 signals your brain to release hormones that control sexual function and testosterone production. Researchers study it because it may naturally boost libido and fertility markers.
Typical dose
1-2 micrograms daily or as needed, injected under the skin or sprayed in the nose. Start with the smallest dose since it's very potent.
When to inject
Morning or shortly before sexual activity, depending on your goals and how your body responds.
Storage
Keep the dry powder in the refrigerator. Once mixed with liquid, store it in the refrigerator and use it within the timeframe specified by your supplier.
First-timer tip
This peptide is extremely strong, so begin with 1 microgram and wait several days to see how you respond before increasing the dose.
On This Page
Research Status
Research compound - clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Usually resolves within 1-2 hours. Rotate injection sites to minimize. Apply ice if needed. Ensure proper site rotation and sterile technique.
Occurs shortly after injection due to rapid hormone elevation. Typically self-resolving within 15-30 minutes. Not dangerous but may be noticeable.
May occur in response to rapid hormonal changes. Usually mild and transient. Stay hydrated and consider timing injections to avoid peak activity periods if bothersome.
Rare but documented in clinical studies. Typically mild and self-resolving. Take with food if it occurs.
Secondary to increased testosterone or other sex hormones. Manage with standard skincare; usually mild if it occurs.
Possible due to hormonal fluctuations. Monitor mood and discontinue if significant emotional disturbance occurs.
Reported in some users, possibly related to rapid hormone elevation. Usually resolves quickly. If persistent, discontinue and consult a healthcare provider.
Preventable through strict site rotation. Use a new site for each injection, maintaining at least 1 inch spacing and 7-day intervals between the same site.
Seek immediate medical attention if any signs of anaphylaxis occur. Discontinue use immediately. Have an epinephrine auto-injector available if you have a history of peptide allergies.
Kisspeptin-10 is extremely potent; overdose can cause exaggerated hormone spikes. Start with the lowest dose (50mcg) and titrate slowly. Monitor for signs of excessive stimulation (severe flushing, palpitations, extreme mood changes).
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-2 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1305.5 |
| Half-life | Approximately 54 minutes (in humans, subcutaneous administration) |
| Sequence | Members only |
Kisspeptin-10 is a neuropeptide that acts as a potent stimulator of GnRH (gonadotropin-releasing hormone) secretion from the hypothalamus. This triggers the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, which regulate reproductive function and sex hormone production. By activating the KISS1R receptor on GnRH neurons, kisspeptin-10 essentially 'unlocks' the reproductive axis, making it a key regulator of puberty, fertility, and sexual function.
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Recent Research
Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.
Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Kisspeptin-10 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.