Gonadorelin
Also known as: GnRH, LHRH, Luteinizing Hormone-Releasing Hormone
Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH). It stimulates the pituitary to release LH and FSH, supporting natural testosterone production and fertility.
Beginner Basics
Plain-English guide to Gonadorelin
What it does
Gonadorelin is a man-made copy of a natural hormone that tells your pituitary gland to release the hormones that trigger testosterone production. Researchers use it to support natural testosterone levels and fertility.
Typical dose
100-200 micrograms injected under the skin or into muscle 2-3 times per week. Some researchers find that spacing out doses (rather than taking all at once) works better.
When to inject
Time of day doesn't matter, but spacing doses evenly throughout the week is more important than picking a specific time.
Storage
Keep the dry powder in the refrigerator before mixing. After you mix it with liquid, store it in the refrigerator and use within a few weeks.
First-timer tip
This peptide works best when dosed regularly and spread out-don't skip doses or bunch them together, as consistency is what keeps your natural hormone system responsive.
On This Page
Research Status
FDA approved for diagnostic use
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Usually self-resolving within 1-2 hours. Minimise by rotating injection sites, allowing the solution to reach room temperature, and using proper injection technique. Apply ice if needed.
May occur in the first few days of use as the HPG axis adjusts. Typically resolves with continued use. Stay hydrated and consider over-the-counter analgesics if needed.
Related to increased testosterone production. Maintain good skin hygiene and consider dermatological consultation if severe.
May occur as testosterone levels rise. Usually mild and transient. Monitor mood and discontinue if symptoms are concerning.
May occur as testicular function increases. Usually resolves within days. Contact a healthcare provider if pain is severe or persistent.
Seek immediate medical attention if you experience difficulty breathing, facial swelling, or severe rash. Discontinue use immediately.
Abrupt discontinuation may cause temporary suppression of endogenous testosterone as the HPG axis re-equilibrates. Taper gradually if discontinuing after prolonged use, or consult a healthcare provider.
Related to increased testosterone and oestrogen conversion. Maintain adequate hydration and monitor sodium intake.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 100-200 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1182.3 |
| Half-life | 2-4 minutes (in vivo); longer when injected subcutaneously due to depot effect |
| Sequence | Members only |
Gonadorelin is a synthetic decapeptide that mimics endogenous gonadotropin-releasing hormone (GnRH). It binds to GnRH receptors on pituitary gonadotroph cells, stimulating the pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This triggers testosterone production in males and supports spermatogenesis and fertility, while avoiding the HPTA (hypothalamic-pituitary-testicular axis) shutdown associated with exogenous testosterone or anabolic steroids.
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Recent Research
Intermittent androgen deprivation therapy for biochemical recurrence or prostate-specific antigen (PSA) persistence after radical prostatectomy: efficacy and prognostic factors.
Cost-effectiveness of degarelix versus LHRH agonists in prostate cancer: a systematic review.
LHRH-Conjugated Magnetite Nanoparticles and Nanorods as Magnetic Resonance Imaging Contrast Agents for Targeting Triple-Negative Breast Cancer.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Gonadorelin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.