Gonadorelin
Also known as: GnRH, LHRH, Luteinizing Hormone-Releasing Hormone
Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH). It stimulates the pituitary to release LH and FSH, supporting natural testosterone production and fertility.
Research Status
FDA approved for diagnostic use
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Usually self-resolving within 1-2 hours. Minimise by rotating injection sites, allowing the solution to reach room temperature, and using proper injection technique. Apply ice if needed.
May occur in the first few days of use as the HPG axis adjusts. Typically resolves with continued use. Stay hydrated and consider over-the-counter analgesics if needed.
Related to increased testosterone production. Maintain good skin hygiene and consider dermatological consultation if severe.
May occur as testosterone levels rise. Usually mild and transient. Monitor mood and discontinue if symptoms are concerning.
May occur as testicular function increases. Usually resolves within days. Contact a healthcare provider if pain is severe or persistent.
Seek immediate medical attention if you experience difficulty breathing, facial swelling, or severe rash. Discontinue use immediately.
Abrupt discontinuation may cause temporary suppression of endogenous testosterone as the HPG axis re-equilibrates. Taper gradually if discontinuing after prolonged use, or consult a healthcare provider.
Related to increased testosterone and oestrogen conversion. Maintain adequate hydration and monitor sodium intake.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 100-200 mcg |
| Frequency | 2-3x weekly |
| Timing | Any time |
| Route | Subcutaneous, Intramuscular |
Pulsatile dosing may be more effective. Prevents HPTA shutdown.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1182.3 |
| Half-life | 2-4 minutes (in vivo); longer when injected subcutaneously due to depot effect |
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
Gonadorelin is a synthetic decapeptide that mimics endogenous gonadotropin-releasing hormone (GnRH). It binds to GnRH receptors on pituitary gonadotroph cells, stimulating the pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This triggers testosterone production in males and supports spermatogenesis and fertility, while avoiding the HPTA (hypothalamic-pituitary-testicular axis) shutdown associated with exogenous testosterone or anabolic steroids.
Hypothalamic-Pituitary-Gonadal (HPG) Axis
Gonadorelin activates GnRH receptors on the anterior pituitary, triggering LH and FSH secretion. LH stimulates Leydig cells to produce testosterone; FSH supports spermatogenesis. This maintains endogenous hormone production rather than suppressing it.
Pulsatile GnRH Signalling
Natural GnRH is released in pulses (every 60-120 minutes). Pulsatile gonadorelin dosing (2-3x weekly) mimics this pattern and is more effective at maintaining LH/FSH secretion than continuous infusion, which causes receptor desensitisation.
Testosterone Production
LH stimulates Leydig cells in the testes to synthesise and release testosterone. Gonadorelin supports this pathway without exogenous testosterone, preserving natural HPTA function and fertility.
- Gonadorelin is a GnRH agonist that stimulates endogenous LH and FSH release, supporting natural testosterone production and fertility
- Pulsatile dosing (2-3x weekly) is more physiologically effective than continuous dosing and prevents receptor desensitisation
- Unlike exogenous testosterone, gonadorelin does not suppress the HPTA and preserves testicular function and spermatogenesis
- Onset of action is rapid (LH/FSH elevation within 15-30 minutes); testosterone elevation typically occurs within 1-2 weeks of consistent dosing
- Gonadorelin is used clinically for hypogonadism, infertility, and delayed puberty in males
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