Bremelanotide
Also known as: PT-141, Vylessi (brand name)
A melanocortin receptor agonist FDA-approved for hypoactive sexual desire disorder in premenopausal women; works centrally to enhance sexual motivation and arousal.
Beginner Basics
Plain-English guide to Bremelanotide
What it does
This peptide works in the brain to increase sexual desire and arousal by activating certain nerve pathways. Researchers study it because it's approved to help women who have low interest in sexual activity.
Typical dose
1.75 mg injected under the skin, used as needed before sexual activity. Maximum once per 24 hours.
When to inject
About 45 minutes before you plan to be sexually active, so it has time to work.
Storage
Keep the dry powder in a cool, dark place at room temperature until you mix it. After mixing with water, refrigerate it and use within 24 hours.
First-timer tip
Plan ahead-set a timer for 45 minutes after injecting so you know when it's reached full effect, rather than guessing.
On This Page
Research Status
FDA-approved
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Occurs in approximately 40% of users, typically mild and transient. Usually resolves within 30 minutes to 1 hour. Taking the injection with food may reduce incidence. Antiemetics (e.g., ginger, ondansetron) may be considered if severe.
Reported in 20–30% of users. Characterized by warmth and redness in the face and neck. Self-resolving and typically lasts 15–30 minutes. Not medically concerning but may be socially noticeable.
Occurs in approximately 5–10% of users. Usually mild and resolves within 1–2 hours. Standard analgesics (acetaminophen, ibuprofen) may be used if needed.
Mild erythema, bruising, or discomfort at the injection site. Minimize by rotating sites, using proper injection technique, and allowing the solution to reach room temperature before injection.
Melanocortin agonists can stimulate melanin production. Rare but documented in clinical trials. Monitor existing moles and report any changes to a dermatologist. Use sunscreen (SPF 30+) during and after treatment.
Transient increases in systolic and diastolic blood pressure have been reported, typically mild and resolving within 1–2 hours. Contraindicated in women with uncontrolled hypertension. Monitor blood pressure before and after injection if history of hypertension.
Reported in a small percentage of users. Sit or lie down if experienced. Ensure adequate hydration before injection.
Melanocortin agonists can affect sexual function in partners exposed to the peptide. Not applicable to the female user but relevant for household safety and storage.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1.75 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1025.2 g/mol |
| Half-life | Approximately 1–2 hours (plasma); effects persist 24–48 hours due to central nervous system retention |
| Sequence | Members only |
Bremelanotide is a melanocortin-4 receptor (MC4R) agonist that acts centrally in the hypothalamus to enhance sexual motivation and arousal in women. By activating MC4R signaling pathways involved in sexual desire, it increases genital sensation and responsiveness without affecting systemic hormone levels. This non-hormonal mechanism makes it suitable for premenopausal women with hypoactive sexual desire disorder.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Bremelanotide is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.