Hexapeptide-9
A cosmetic peptide that modulates neuropeptide signaling to reduce skin inflammation and improve barrier function, used in anti-aging skincare formulations.
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Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in individuals with sensitive skin or during initial use. Typically resolves within 1-2 weeks with continued use. If persistent, discontinue and consult a dermatologist.
Some users report mild itching at the application site. This is usually transient and resolves as the skin acclimates to the product.
Possible in individuals with peptide sensitivity or allergy to other formulation ingredients. Perform a patch test before full application. Discontinue immediately if severe rash, swelling, or difficulty breathing occurs.
Some formulations may cause temporary dryness. Use a compatible moisturizer to counteract this effect.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | - |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Hexapeptide-9 modulates neuropeptide signaling pathways in the skin, particularly reducing the release of pro-inflammatory neuropeptides such as substance P. By dampening neurogenic inflammation, it decreases skin irritation, redness, and inflammatory responses. This mechanism supports improved barrier function and may reduce the appearance of age-related skin changes associated with chronic inflammation.
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Recent Research
A framework for the safety evaluation of peptides in cosmetics.
Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
3 sources
Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-349. PMID: 18045356
Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. PMID: 19624666
Blanes-Mira C, Clemente C, Joly-Tonetti N, et al. A synthetic hexapeptide (Argireline) modulates proinflammatory and anti-inflammatory cytokines in LPS-stimulated monocytes. Peptides. 2002;23(8):1319-1326. PMID: 12182941
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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Hexapeptide-9 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.