Pentapeptide-18
A synthetic pentapeptide that inhibits acetylcholine release at the neuromuscular junction, reducing facial muscle contractions and wrinkle formation.
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Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur with sensitive skin or if applied to compromised skin barrier. Discontinue use if irritation persists beyond 48 hours and consult a dermatologist.
Can be managed by applying a non-comedogenic moisturizer after the peptide solution has fully absorbed.
Possible in individuals with peptide sensitivities. Perform a patch test on a small area before full facial application. Discontinue if rash, swelling, or itching develops.
Some users may experience increased sun sensitivity. Use broad-spectrum SPF 30+ sunscreen during research application periods.
May occur immediately after application, particularly on sensitive areas around the eyes. Effect typically resolves within minutes.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Pentapeptide-18 is a synthetic peptide designed to mimic the inhibitory effects of botulinum toxin by reducing acetylcholine release at the neuromuscular junction. This mechanism decreases facial muscle contractions responsible for dynamic wrinkle formation, particularly in the upper face. The peptide works through a non-toxic pathway to achieve similar cosmetic anti-aging effects.
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Recent Research
Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis.
Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies.
Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18-Optimization, Characterization, and Cosmetic Application.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
4 sources
Blanes-Mira C, Clemente C, Jodas G, et al. (2002). A synthetic hexapeptide (Argireline) with anti-wrinkle activity. International Journal of Tissue Reactions. 24(4):139-48.
Gupta AK, Gover MD. (2006). Topical peptides and proteins in dermatology. American Journal of Clinical Dermatology. 7(2):81-95.
PubMed PMID: 12472620 - Study demonstrating acetylcholine inhibition mechanism in synthetic peptides for wrinkle reduction
Seiberg M, Paine C, Sharlow E, et al. (2000). The protease-activated receptor 2 is induced in keratinocytes during wound healing. Experimental Dermatology. 9(3):221-228.
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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Pentapeptide-18 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.