SS-31
Also known as: Elamipretide, MTP-131
Also known as Elamipretide, this mitochondrial-targeted peptide concentrates in the inner mitochondrial membrane to restore cellular energy production. Has cardioprotective and neuroprotective properties.
Beginner Basics
Plain-English guide to SS-31
What it does
This peptide targets the energy-producing centers inside your cells (mitochondria) to help them work better and produce more energy. Researchers study it because it may protect heart and nerve tissue from damage and reduce cellular stress.
Typical dose
Researchers typically start with 0.25 mg and gradually increase up to 5 mg, given once daily as a subcutaneous injection (under the skin).
When to inject
You can inject at any time of day-timing doesn't matter for this one.
Storage
Keep the dry powder in a freezer at -20°C. Once you mix it with liquid, store it in a regular refrigerator (2-8°C) and keep it away from light.
First-timer tip
Start with the lowest dose (0.25 mg) and only increase it slowly based on how you feel and any side effects-this helps your body adjust and lets you find what works best for you.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild erythema, swelling, or discomfort at the injection site. Usually resolves within 24 hours. Minimize by rotating injection sites, allowing solution to reach room temperature, and using proper injection technique.
Mild headache reported in some clinical trial participants. Typically transient and resolves without intervention. Ensure adequate hydration.
Mild nausea reported rarely in clinical trials. Usually self-resolving. Take with food if tolerated.
Mild fatigue or tiredness reported in some users. May improve with continued use as mitochondrial function normalizes. Ensure adequate sleep and nutrition.
Rare reports of mild dizziness. Sit or lie down if this occurs. Ensure adequate hydration and blood pressure monitoring.
Localized fat loss or thickening at repeated injection sites. Prevent by rotating injection sites systematically with each dose. Space injections at least 1 inch apart.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.25-5 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 887.04 Da |
| Half-life | Approximately 1-2 hours in plasma; tissue half-life longer due to mitochondrial accumulation |
| Sequence | Members only |
SS-31 (elamipretide) is a mitochondrial-targeted peptide that crosses the blood-brain barrier and concentrates in the inner mitochondrial membrane, where it binds to cardiolipin and restores electron transport chain function. By stabilizing the cardiolipin-cytochrome c complex, it reduces reactive oxygen species (ROS) production and enhances ATP synthesis, thereby restoring cellular energy metabolism. This mechanism provides cardioprotective and neuroprotective effects in conditions characterized by mitochondrial dysfunction.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. SS-31 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.