Skin & Anti-Aging / Subcutaneous / Intramuscular
Epithalon
Also known as Epitalon, Epithalone
Epithalon is a synthetic tetrapeptide that acts as a telomerase activator. It is derived from epithalamin, a pineal gland extract. Epithalon may lengthen telomeres and has been studied for its potential anti-aging and longevity effects.
What is Epithalon used for? Research has focused on telomerase activation (may lengthen telomeres); anti-aging properties; regulates melatonin production.
Compare with other peptides studied forlongevity and anti-aging,better sleep,cognitive performance
Epithalon injection at a glance
Figures from the published research literature. Research use only.
- Dose range
- 5-10 mg
- Route
- Subcutaneous, Intramuscular
How often, when, and the dosing notes are in the dosing reference further down.
Work out your units in the free calculatorBeginner basics
Plain-English guide to Epithalon
- What it does
- Epithalon is a small protein fragment that researchers study for its potential to activate an enzyme called telomerase, which may help protect the ends of your DNA strands (called telomeres) that naturally wear down with age. It's commonly researched for anti-aging effects and may help regulate your sleep-wake cycle.
- Typical dose
- Researchers typically use 5-10 mg per day, given as an injection under the skin or into muscle, usually for 10-20 days at a time.
- When to inject
- Morning injections are typical, and researchers usually run cycles of 10-20 days, then take a break, repeating this 2-4 times per year.
- Storage
- Keep the dry powder in the refrigerator before mixing; once you mix it with liquid, store it in the refrigerator and use it within the timeframe noted on your product.
- Beginner tip
- Start with the lower end of the dose range (5 mg) and stick to the 10-20 day cycle pattern rather than using it continuously-this cycling approach is how researchers typically study it.
Research status
- Evidence grade B
- Smaller human trials, observational studies, or approved in 30 or more countries.
- Research only
- No regulatory approval in any major jurisdiction. Research use only.
Research compound with significant Russian research
For research purposes only. Not approved for human use. Not medical advice.
Research areas
- Telomerase activation (may lengthen telomeres)
- Anti-aging properties
- Regulates melatonin production
- May increase lifespan
- Improves sleep quality
- Supports circadian rhythm regulation
- May have neuroprotective effects
Side effects
| Effect | How often | Severity |
|---|---|---|
| Injection site reactionsMild redness, swelling, or itching at the injection site typically resolves within 1-2 hours. Rotate injection sites to minimize local irritation. Ensure the injection site is clean and dry before administration. | Common | Mild |
| HeadacheMild headaches have been reported in some users, typically during the first few days of a cycle. Usually self-resolving; ensure adequate hydration and rest. | Uncommon | Mild |
| Dizziness or lightheadednessTransient dizziness may occur shortly after injection. Sit or lie down if this occurs. Ensure you are well-hydrated and have eaten before injecting. | Uncommon | Mild |
| NauseaMild nausea has been reported in some users. Usually resolves within 1-2 hours. Taking the injection with food or after a meal may help reduce this effect. | Uncommon | Mild |
| Allergic reaction (localized)Localized allergic reactions (urticaria, severe swelling) at the injection site are rare but possible. If severe localized swelling or rash develops, discontinue use and seek medical evaluation. Anaphylaxis is extremely rare but would require immediate emergency medical attention. | Rare | Moderate |
| Lipodystrophy (localized fat loss or thickening)Repeated injections in the same site can cause localized fat loss (lipoatrophy) or fat thickening (lipohypertrophy). Prevent this by systematically rotating injection sites and maintaining at least 1 inch spacing between injection points. This effect is reversible if site rotation is implemented. | Uncommon | Moderate |
| Fever or chillsTransient low-grade fever or chills have been rarely reported. Usually self-resolving within 24 hours. If fever persists or is accompanied by other symptoms, seek medical evaluation to rule out infection. | Rare | Mild |
Dosing reference
Dose scale from the research
- Starting
- 5 mg
- Upper end
- 10 mg
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
Frequency, timing and route are for members | |
Checked October 2026
Research disclaimer. Figures are drawn from published research literature and community logs. They are not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution guide
- Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
- Do not shake the vial vigorously; gentle swirling prevents peptide degradation
- Discard immediately if the solution appears cloudy, discolored, or contains visible particles
- Use within 30 days of reconstitution when stored at 2-8°C
- Do not freeze the reconstituted solution; freezing may denature the peptide
- Use the PeptideVolt reconstitution calculator for your exact concentration
Worked example
With 5 mg in the vial, the water you add changes the draw. Mixed with 1 mL that is 5,000 mcg per mL, so on a U-100 syringe 5 mg is 100 units and 10 mg is 200 units. Mixed with 2 mL it is 2,500 mcg per mL, so 5 mg is 200 units and 10 mg is 400 units.
Storage and stability
Refrigerate after reconstitution.
Molecular and pharmacological data
| Molecular weight | 390 |
|---|---|
| Sequence | Members only |
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that acts as a telomerase activator, derived from the pineal gland extract epithalamin. It is theorized to stimulate telomerase activity in cells, potentially lengthening telomeres (the protective caps on chromosomes that shorten with age), thereby promoting cellular longevity and anti-aging effects. The peptide may also modulate circadian rhythm regulation and pineal gland function, contributing to its proposed anti-aging mechanisms.
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Recent research
All results on PubMedOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Araj SK, et al. / International journal of molecular sciences / 2025
Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.
Khavinson VKh, et al. / Bulletin of experimental biology and medicine / 2012
Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Vinogradova IA, et al. / Bulletin of experimental biology and medicine / 2008
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research citations
2 sources
Epithalon and telomerase activation
Khavinson bioregulatory peptides
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Research use only. All content on this page is provided for informational and educational purposes related to scientific research. Epithalon is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.