Epithalon
Also known as: Epitalon, Epithalone
Epithalon is a synthetic tetrapeptide that acts as a telomerase activator. It is derived from epithalamin, a pineal gland extract. Epithalon may lengthen telomeres and has been studied for its potential anti-aging and longevity effects.
Beginner Basics
Plain-English guide to Epithalon
What it does
Epithalon is a small protein fragment that researchers study for its potential to activate an enzyme called telomerase, which may help protect the ends of your DNA strands (called telomeres) that naturally wear down with age. It's commonly researched for anti-aging effects and may help regulate your sleep-wake cycle.
Typical dose
Researchers typically use 5-10 mg per day, given as an injection under the skin or into muscle, usually for 10-20 days at a time.
When to inject
Morning injections are typical, and researchers usually run cycles of 10-20 days, then take a break, repeating this 2-4 times per year.
Storage
Keep the dry powder in the refrigerator before mixing; once you mix it with liquid, store it in the refrigerator and use it within the timeframe noted on your product.
First-timer tip
Start with the lower end of the dose range (5 mg) and stick to the 10-20 day cycle pattern rather than using it continuously-this cycling approach is how researchers typically study it.
On This Page
Research Status
Research compound with significant Russian research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild redness, swelling, or itching at the injection site typically resolves within 1-2 hours. Rotate injection sites to minimize local irritation. Ensure the injection site is clean and dry before administration.
Mild headaches have been reported in some users, typically during the first few days of a cycle. Usually self-resolving; ensure adequate hydration and rest.
Transient dizziness may occur shortly after injection. Sit or lie down if this occurs. Ensure you are well-hydrated and have eaten before injecting.
Mild nausea has been reported in some users. Usually resolves within 1-2 hours. Taking the injection with food or after a meal may help reduce this effect.
Localized allergic reactions (urticaria, severe swelling) at the injection site are rare but possible. If severe localized swelling or rash develops, discontinue use and seek medical evaluation. Anaphylaxis is extremely rare but would require immediate emergency medical attention.
Repeated injections in the same site can cause localized fat loss (lipoatrophy) or fat thickening (lipohypertrophy). Prevent this by systematically rotating injection sites and maintaining at least 1 inch spacing between injection points. This effect is reversible if site rotation is implemented.
Transient low-grade fever or chills have been rarely reported. Usually self-resolving within 24 hours. If fever persists or is accompanied by other symptoms, seek medical evaluation to rule out infection.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 390 |
| Sequence | Members only |
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that acts as a telomerase activator, derived from the pineal gland extract epithalamin. It is theorized to stimulate telomerase activity in cells, potentially lengthening telomeres (the protective caps on chromosomes that shorten with age), thereby promoting cellular longevity and anti-aging effects. The peptide may also modulate circadian rhythm regulation and pineal gland function, contributing to its proposed anti-aging mechanisms.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Epithalon is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.