Epithalon
Also known as: Epitalon, Epithalone
Epithalon is a synthetic tetrapeptide that acts as a telomerase activator. It is derived from epithalamin, a pineal gland extract. Epithalon may lengthen telomeres and has been studied for its potential anti-aging and longevity effects.
Research Status
Research compound with significant Russian research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild redness, swelling, or itching at the injection site typically resolves within 1-2 hours. Rotate injection sites to minimize local irritation. Ensure the injection site is clean and dry before administration.
Mild headaches have been reported in some users, typically during the first few days of a cycle. Usually self-resolving; ensure adequate hydration and rest.
Transient dizziness may occur shortly after injection. Sit or lie down if this occurs. Ensure you are well-hydrated and have eaten before injecting.
Mild nausea has been reported in some users. Usually resolves within 1-2 hours. Taking the injection with food or after a meal may help reduce this effect.
Localized allergic reactions (urticaria, severe swelling) at the injection site are rare but possible. If severe localized swelling or rash develops, discontinue use and seek medical evaluation. Anaphylaxis is extremely rare but would require immediate emergency medical attention.
Repeated injections in the same site can cause localized fat loss (lipoatrophy) or fat thickening (lipohypertrophy). Prevent this by systematically rotating injection sites and maintaining at least 1 inch spacing between injection points. This effect is reversible if site rotation is implemented.
Transient low-grade fever or chills have been rarely reported. Usually self-resolving within 24 hours. If fever persists or is accompanied by other symptoms, seek medical evaluation to rule out infection.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
| Frequency | Daily for 10-20 days |
| Timing | Morning |
| Route | Subcutaneous, Intramuscular |
Used in 10-20 day cycles, repeated 2-4 times per year. Developed by Russian researcher Vladimir Khavinson.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 390 |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that acts as a telomerase activator, derived from the pineal gland extract epithalamin. It is theorized to stimulate telomerase activity in cells, potentially lengthening telomeres (the protective caps on chromosomes that shorten with age), thereby promoting cellular longevity and anti-aging effects. The peptide may also modulate circadian rhythm regulation and pineal gland function, contributing to its proposed anti-aging mechanisms.
Telomerase Activation
Epithalon is proposed to upregulate telomerase reverse transcriptase (TERT) expression and activity, leading to telomere elongation in somatic cells. Telomere shortening is associated with cellular senescence and aging; by extending telomeres, the peptide may theoretically extend cellular replicative lifespan.
Pineal Gland Modulation
Epithalon is derived from pineal gland extract and may enhance pineal function, including melatonin production and circadian rhythm regulation. Improved circadian function and melatonin levels are associated with enhanced antioxidant defense and cellular repair mechanisms.
Antioxidant and Cytoprotective Effects
Preclinical studies suggest epithalon may enhance cellular antioxidant defenses and reduce oxidative stress, contributing to protection against age-related cellular damage and supporting longevity pathways.
- Epithalon is a tetrapeptide (4 amino acids) originally isolated from bovine pineal gland extracts by Russian researcher Vladimir Khavinson
- The peptide is proposed to activate telomerase, an enzyme that extends telomeres and may slow cellular aging
- Most human data on epithalon comes from Russian clinical studies; Western peer-reviewed evidence is limited
- The peptide is administered in short cycles (10-20 days) repeated 2-4 times annually, not as continuous therapy
- Epithalon is not approved by the FDA or EMA; it is used as a research peptide in many countries
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