FOXO4-DRI
A senolytic peptide that selectively targets and eliminates senescent (zombie) cells by disrupting the FOXO4-p53 interaction. Being researched for anti-aging and tissue rejuvenation applications.
Beginner Basics
Plain-English guide to FOXO4-DRI
What it does
This peptide targets and removes 'zombie cells'-old, damaged cells that accumulate in skin and tissues over time. Researchers study it for potentially improving skin firmness and supporting the body's natural repair processes.
Typical dose
Researchers commonly use 5-10 mg applied topically three times per week, often applied as a cream or lotion with 0.1-1% concentration. Dosing varies widely in research, so start with a lower amount and adjust based on how your skin responds.
When to inject
Topical application can be done any time of day. Many researchers cycle it (8 weeks on, 4 weeks off) to monitor effects and prevent the body from adapting to it.
Storage
Keep the dry powder in a freezer at -20°C before mixing. Once you mix it with liquid, store it in a regular refrigerator (2-8°C). Keep it away from direct light.
First-timer tip
Start with the lowest recommended amount and use it consistently for at least 4-8 weeks before deciding if it's working, since skin changes take time to become visible.
On This Page
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Redness, mild swelling, or bruising at the injection site. Usually resolves within 24-48 hours. Minimize by rotating sites, allowing solution to reach room temperature, and using proper injection technique.
Mild stinging or soreness during or immediately after injection. Typically resolves within minutes. Reduced by allowing the peptide solution to warm to room temperature before injection.
Repeated injections at the same site can cause localized fat loss (lipoatrophy) or fat thickening (lipohypertrophy). Prevent by strictly rotating injection sites with each dose and maintaining at least 1 inch between injection points.
Transient fever, malaise, or mild systemic inflammation may occur as senescent cells are cleared and release inflammatory mediators. This is theoretically possible but not well-documented in human studies. Monitor and contact a healthcare provider if symptoms are severe.
Anaphylaxis or severe allergic reaction is rare but possible with any peptide. Signs include difficulty breathing, facial swelling, severe itching, or rapid heartbeat. Seek emergency medical attention immediately if these occur.
Bacterial infection can occur if sterile technique is not followed. Signs include increasing redness, warmth, pus, or fever. Seek medical attention if infection is suspected.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
FOXO4-DRI is a senolytic peptide that disrupts the interaction between the FOXO4 protein and p53 in senescent cells, leading to their selective apoptosis (programmed cell death). Senescent cells accumulate with age and contribute to tissue dysfunction and inflammation. By eliminating these 'zombie' cells, FOXO4-DRI aims to restore tissue homeostasis and support regeneration.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. FOXO4-DRI is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.