GHK
Also known as: Glycyl-L-Histidyl-L-Lysine, GHK without copper
GHK is a naturally occurring tripeptide with wound healing and anti-aging properties. Unlike GHK-Cu, it does not contain copper and may have different bioavailability.
Beginner Basics
Plain-English guide to GHK
What it does
GHK is a natural three-amino-acid chain that researchers study for skin repair and anti-aging, working by encouraging your body to make more collagen and elastin (the proteins that keep skin firm and smooth).
Typical dose
Researchers commonly use 1-3 mg per day, either injected under the skin or applied directly to the skin as a cream or serum.
When to inject
Timing doesn't matter for this peptide-you can inject or apply it whenever is convenient for you.
Storage
Keep the dry powder in the refrigerator before mixing; once you mix it with water, store it in the refrigerator and use it within the timeframe specified by your supplier.
First-timer tip
If you're new to peptides, start with topical application first since it's less intimidating than injections, then try subcutaneous injections once you're comfortable with the process.
On This Page
Research Status
Research compound - used in cosmetics
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Redness, mild swelling, or bruising at the injection site typically resolve within 24-48 hours. Minimize by rotating sites, using proper injection technique, and allowing the solution to reach room temperature before injection.
May occur immediately after injection and usually resolves within minutes to hours. Not a sign of allergy unless accompanied by systemic symptoms.
Reported anecdotally in some users; may be related to hydration status or individual sensitivity. Ensure adequate water intake.
Transient vasodilation may occur in sensitive individuals. Typically resolves within 30 minutes.
Reported rarely; may be dose-dependent. Take with food if this occurs.
Although rare, peptide allergies are possible. Discontinue immediately and seek medical attention if you develop hives, difficulty breathing, or facial swelling. Individuals with known peptide allergies should avoid use.
Prolonged use at the same injection site can cause localised fat loss. Prevent by strictly rotating injection sites with each dose and spacing injections at least 1 inch apart.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-3 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 346.4 Da |
| Half-life | Estimated 30 minutes to 1 hour in circulation (varies by route and individual metabolism) |
| Sequence | Members only |
GHK is a naturally occurring tripeptide (glycine-histidine-lysine) that promotes wound healing, collagen synthesis, and tissue remodeling through multiple signaling pathways. Unlike GHK-Cu (which contains copper), free GHK acts primarily through growth factor modulation and direct cellular signaling, with potential anti-inflammatory and antioxidant effects. It is thought to enhance skin barrier function and promote fibroblast activity, making it relevant for anti-aging and dermatological applications.
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Recent Research
Glycyl-L-histidyl-L-lysine-Cu2(+) (GHK-Cu) Attenuates CuSO(4) or LPS induced-inflammation in Zebrafish larvae model.
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Glycyl-l-histidyl-l-lysine as a novel co-former in co-amorphous systems: Enhanced aqueous solubility and physical stability.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. GHK is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.