Humanin
Also known as: HN, Humanin-G
A mitochondrial-derived peptide with potent neuroprotective and anti-apoptotic properties. Naturally produced in the body and associated with longevity and metabolic health.
Beginner Basics
Plain-English guide to Humanin
What it does
Humanin is a naturally occurring protein fragment that helps protect your cells from damage and supports energy production within cells. Researchers study it for its potential to support brain health, metabolism, and aging-related concerns.
Typical dose
Researchers typically use 1-5 mg applied topically once daily, starting at the lower end to see how your body responds.
When to inject
You can apply it any time of day since it's used topically on the skin.
Storage
Keep the dry powder in the freezer at -20°C. After mixing with liquid, store it in the refrigerator between 2-8°C and keep it away from light.
First-timer tip
Start with the lowest dose (1 mg) and use it consistently for at least 2-4 weeks before deciding if you need to adjust, since these peptides work gradually.
On This Page
Research Status
Preclinical/Research Phase
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Redness, mild swelling, or itching at injection site. Usually resolves within hours. Minimize by rotating sites, allowing solution to reach room temperature, and using proper injection technique.
Mild headache reported in some users. Typically transient. Ensure adequate hydration and monitor timing relative to injections.
Transient facial flushing reported in isolated cases. Self-resolving and does not require intervention.
Mild nausea reported in very few users. May be dose-dependent. Consider taking with food or reducing dose if persistent.
Localized fat loss or thickening at repeated injection sites. Preventable through strict site rotation (minimum 1 inch between sites, cycle through 4-6+ sites). Discontinue injections at affected sites until resolved.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-5 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 2174 |
| Sequence | Members only |
Humanin is a mitochondrial-derived peptide that activates multiple cytoprotective signaling pathways, including JAK/STAT and PI3K/Akt, to suppress apoptosis and enhance cellular stress resistance. It improves mitochondrial function and bioenergetics, reducing oxidative stress and inflammation while enhancing metabolic health and neuroprotection. These mechanisms underlie its reported effects on longevity, cognitive function, and metabolic regulation.
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Recent Research
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.
Arsenic Promotes Intracellular Aβ((1-42)) Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells.
Characterization of the Effects of a Humanin Fragment Peptide (HNF(14)) in Age-Related Macular Degeneration.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Humanin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.