VIP
Also known as: Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide
VIP is a neuropeptide with wide-ranging effects including immune modulation, neuroprotection, and treatment of chronic inflammatory response syndrome (CIRS).
Beginner Basics
Plain-English guide to VIP
What it does
VIP is a natural signaling molecule that helps calm down an overactive immune system and reduce inflammation throughout the body. Researchers commonly use it to help people with chronic inflammatory conditions, including those related to mold exposure.
Typical dose
50 micrograms sprayed into the nose four times per day, spaced about 4-6 hours apart.
When to inject
Space doses evenly throughout the day (roughly every 4-6 hours), such as morning, midday, late afternoon, and evening. Timing flexibility is acceptable as long as doses don't bunch together.
Storage
Keep the dry powder in the refrigerator between 36-46°F (2-8°C) until you mix it. Once mixed with saline, store in the refrigerator and use within the timeframe your supplier recommends.
First-timer tip
Use a nasal spray bottle for consistency and to ensure the peptide reaches the nasal passages properly-this matters more than injecting since it's absorbed through the nose, not under the skin.
On This Page
Research Status
Research compound - used clinically for CIRS
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Transient vasodilation, typically occurs within minutes of injection and resolves within 15-30 minutes. More common with higher doses or rapid injection. Manage by slowing injection speed and allowing solution to warm to room temperature.
Mild to moderate headache may occur, particularly with intranasal administration. Usually self-resolving within 1-2 hours. Stay hydrated and rest in a quiet environment if needed.
Transient nasal inflammation or congestion may occur with intranasal VIP. Typically resolves within hours. Use saline rinse if needed; do not use decongestants without consulting your healthcare provider.
Mild nausea may occur, especially at higher doses or on an empty stomach. Manage by taking with food or reducing dose. Resolves within 1-2 hours in most cases.
May occur due to vasodilation or rapid absorption. Sit or lie down if this occurs. Ensure adequate hydration and avoid sudden position changes.
Mild erythema, itching, or swelling at the injection site may occur. Rotate injection sites to minimise lipodystrophy. Apply ice if swelling is bothersome.
VIP is a vasodilator and may lower blood pressure, particularly at higher doses. Monitor blood pressure regularly. Inform your healthcare provider if you are taking antihypertensive medications. Seek medical attention if dizziness or syncope occurs.
Compensatory tachycardia may occur in response to vasodilation. Usually mild and transient. Monitor heart rate; seek medical attention if palpitations or chest discomfort occur.
Anaphylaxis or severe allergic reaction is rare but possible. Symptoms include urticaria, angioedema, bronchospasm, or hypotension. Seek immediate emergency medical attention if any signs of anaphylaxis develop. Have an epinephrine auto-injector available if you have a history of peptide allergies.
Some CIRS patients report transient worsening of symptoms (cytokine release reaction) in the first 1-2 weeks of VIP therapy, attributed to immune system reactivation. This may include fever, malaise, or exacerbation of existing symptoms. Typically resolves as treatment continues. Inform your healthcare provider if symptoms worsen significantly.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 50 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 3357 |
| Half-life | 1-2 minutes (in circulation; longer in tissue compartments) |
| Sequence | Members only |
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide that acts as a neuroimmune modulator, binding to VPAC1 and VPAC2 G-protein coupled receptors throughout the nervous and immune systems. It exerts anti-inflammatory effects by suppressing pro-inflammatory cytokine production (TNF-α, IL-6, IL-8), promoting regulatory T cell differentiation, and enhancing parasympathetic nervous system signalling. VIP also provides neuroprotection and has been investigated for treatment of chronic inflammatory response syndrome (CIRS) and mast cell activation disorders.
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Recent Research
Psilocybin reshapes cortical inhibition through selective interneuron recruitment.
Opposing behavioral roles for a single gene in a species with a supergene polymorphism.
Osteoprotective effects of the neuropeptide VIP: insights from triple cultures of human osteocytes, osteoblasts, and osteoclasts.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. VIP is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.