Tesofensine
Also known as: NN7952
Triple monoamine reuptake inhibitor that significantly suppresses appetite and increases energy expenditure. Originally developed for neurological conditions, repurposed for obesity treatment.
Beginner Basics
Plain-English guide to Tesofensine
What it does
This compound works by increasing a brain chemical that reduces hunger and makes your body burn more calories throughout the day. Researchers study it for weight loss because it makes people feel less hungry and more energetic.
Typical dose
Researchers typically start with 0.25 mg by mouth once daily, then increase by 0.25 mg every 4 weeks up to a maximum of 1 mg daily, depending on how well someone tolerates it.
When to inject
Take it in the morning with or without food. Morning timing helps with the energy-boosting effects throughout the day.
Storage
Keep the dry powder in a freezer at -20°C (around -4°F). Once mixed with liquid, store it in a regular refrigerator at 2-8°C (35-46°F) and keep it away from direct light.
First-timer tip
Start at the lowest dose (0.25 mg) and give your body at least 4 weeks to adjust before increasing-this helps you see how you actually respond without jumping to higher amounts too quickly.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Often transient and resolves within 1-2 weeks. Take with food if tolerated. Dose titration reduces incidence.
Due to increased dopamine and norepinephrine. Take dose in early morning (6-8 AM). Avoid evening dosing. May improve with continued use.
Dose-dependent effect. Monitor heart rate regularly. Baseline and periodic cardiovascular assessment recommended. Discontinue if sustained elevation or palpitations occur.
Noradrenergic effect. Monitor blood pressure at baseline and regularly during treatment. Contraindicated in uncontrolled hypertension.
Usually mild and transient. May respond to over-the-counter analgesics.
Increase water intake. Use sugar-free lozenges if needed.
Dose-dependent. May occur during titration phase. Consider slower dose escalation.
Fine tremor may occur, particularly at higher doses. Usually resolves with dose reduction or continued use.
Increased thermogenesis and sympathetic activation. Usually mild and transient.
Increased fiber intake and hydration recommended. Stool softeners may help if needed.
Risk if combined with other serotonergic agents (SSRIs, SNRIs, MAOIs, tramadol). Symptoms include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, muscle rigidity. Requires immediate medical attention. Contraindicated with serotonergic medications.
Mood changes, suicidal ideation, or behavioral changes reported in some users. Monitor mental health closely. Discontinue and seek medical evaluation if psychiatric symptoms emerge.
Cardiac arrhythmias possible, particularly in susceptible individuals or at higher doses. Baseline ECG recommended. Discontinue immediately if arrhythmia suspected.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.25-1 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Half-life | Approximately 20-24 hours (oral) |
Tesofensine is a triple monoamine reuptake inhibitor that blocks the reuptake of serotonin, norepinephrine, and dopamine in the central nervous system. By increasing synaptic concentrations of these neurotransmitters, it suppresses appetite through hypothalamic pathways and increases energy expenditure, promoting weight loss. It was originally developed for neurological conditions but has been repurposed for obesity treatment due to its potent metabolic effects.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Tesofensine is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.