Tabimorelin
An oral ghrelin mimetic that stimulates GH release and appetite. Research stage with potential for cachexia treatment.
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Expected pharmacological effect; may be therapeutic in cachexia but problematic in obesity. Manage by monitoring caloric intake and food choices.
Ghrelin agonists may transiently elevate cortisol; monitor if using long-term. Baseline and periodic cortisol testing recommended.
May occur with oral administration. Take with food if GI upset develops; usually resolves with continued use.
Reported in some users; typically mild and self-resolving. Ensure adequate hydration.
GH secretagogues may increase water retention. Monitor weight and lower extremity swelling; discontinue if significant edema develops.
GH excess can antagonize insulin action. Monitor fasting glucose and HbA1c, especially in those with metabolic risk factors.
May occur with rapid GH elevation. Usually mild and transient.
Long-term GH excess can cause carpal tunnel; monitor for wrist pain or paresthesias with extended use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-25 mcg |
| Frequency | 1-3x daily |
| Timing | Before meals or before bed |
| Route | Oral |
Oral administration. Research compound — not approved for human use. Start at lower end (5 mcg) and titrate based on response. Take with or without food, though timing relative to meals may affect appetite stimulation.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Tabimorelin is an oral ghrelin receptor agonist (mimetic) that binds to the growth hormone secretagogue receptor (GHSR-1a) on pituitary somatotroph cells and hypothalamic neurons. This activation stimulates the release of growth hormone and increases appetite signaling through central ghrelin pathways. The compound was designed to provide oral bioavailability for GH secretion and appetite stimulation, with potential applications in cachexia, wasting syndromes, and age-related GH decline.
GHSR-1a Activation
Tabimorelin binds to growth hormone secretagogue receptor type 1a on pituitary somatotrophs, triggering GH release via increased intracellular calcium and IP3 signaling
Hypothalamic GH-RH Stimulation
Activation of GHSR-1a on hypothalamic neurons increases GH-releasing hormone (GH-RH) secretion, which synergizes with direct pituitary effects
Appetite Regulation
Ghrelin receptor agonism activates orexigenic neurons in the arcuate nucleus, increasing appetite and food intake via NPY/AgRP pathways
Somatostatin Inhibition
GHSR-1a signaling suppresses somatostatin release from hypothalamic neurons, removing tonic GH inhibition
- Tabimorelin is a non-peptide small-molecule ghrelin mimetic with oral bioavailability
- Binds selectively to GHSR-1a (growth hormone secretagogue receptor type 1a)
- Stimulates pulsatile GH secretion similar to endogenous ghrelin
- Increases appetite and food intake through central ghrelin signaling
- Designed to address GH deficiency and cachexia in research settings
- Oral administration avoids injection-related complications
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