Tabimorelin
An oral ghrelin mimetic that stimulates GH release and appetite. Research stage with potential for cachexia treatment.
Beginner Basics
Plain-English guide to Tabimorelin
What it does
Tabimorelin signals your body to produce more growth hormone and stimulates appetite. Researchers study it for helping people regain muscle and weight, especially those with serious wasting conditions.
Typical dose
5 to 25 micrograms taken by mouth once to three times daily, starting at the lower end and adjusting based on how you respond.
When to inject
Take before meals or before bed. Timing around food may affect how much it boosts your appetite, so experiment to find what works for you.
Storage
Keep the dry powder frozen at -20°C (about -4°F). After mixing with liquid, refrigerate it at 2-8°C (35-46°F) and keep it away from light.
First-timer tip
Start with 5 micrograms to see how your body responds before moving to higher doses-this is still an experimental compound being studied by researchers.
On This Page
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Expected pharmacological effect; may be therapeutic in cachexia but problematic in obesity. Manage by monitoring caloric intake and food choices.
Ghrelin agonists may transiently elevate cortisol; monitor if using long-term. Baseline and periodic cortisol testing recommended.
May occur with oral administration. Take with food if GI upset develops; usually resolves with continued use.
Reported in some users; typically mild and self-resolving. Ensure adequate hydration.
GH secretagogues may increase water retention. Monitor weight and lower extremity swelling; discontinue if significant edema develops.
GH excess can antagonize insulin action. Monitor fasting glucose and HbA1c, especially in those with metabolic risk factors.
May occur with rapid GH elevation. Usually mild and transient.
Long-term GH excess can cause carpal tunnel; monitor for wrist pain or paresthesias with extended use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-25 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Tabimorelin is an oral ghrelin receptor agonist (mimetic) that binds to the growth hormone secretagogue receptor (GHSR-1a) on pituitary somatotroph cells and hypothalamic neurons. This activation stimulates the release of growth hormone and increases appetite signaling through central ghrelin pathways. The compound was designed to provide oral bioavailability for GH secretion and appetite stimulation, with potential applications in cachexia, wasting syndromes, and age-related GH decline.
Track your Tabimorelin research
Free account. No credit card required.
Recent Research
Comprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes.
Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats.
A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Browse the Research Library
40+ peptide profiles with mechanism summaries, dosing data, and reconstitution guides.
View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Tabimorelin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.