Growth Hormone Secretagogues / Oral
Tabimorelin
An oral ghrelin mimetic that stimulates GH release and appetite. Research stage with potential for cachexia treatment.
What is Tabimorelin used for? Research has focused on stimulates growth hormone secretion; increases appetite and food intake; may improve muscle mass and body composition.
Compare with other peptides studied formuscle growth
Beginner basics
Plain-English guide to Tabimorelin
- What it does
- Tabimorelin signals your body to produce more growth hormone and stimulates appetite. Researchers study it for helping people regain muscle and weight, especially those with serious wasting conditions.
- Typical dose
- 5 to 25 micrograms taken by mouth once to three times daily, starting at the lower end and adjusting based on how you respond.
- When to inject
- Take before meals or before bed. Timing around food may affect how much it boosts your appetite, so experiment to find what works for you.
- Storage
- Keep the dry powder frozen at -20°C (about -4°F). After mixing with liquid, refrigerate it at 2-8°C (35-46°F) and keep it away from light.
- Beginner tip
- Start with 5 micrograms to see how your body responds before moving to higher doses-this is still an experimental compound being studied by researchers.
Research status
- Evidence grade C
- Mostly animal or in-vitro studies, with limited human data.
- Research only
- No regulatory approval in any major jurisdiction. Research use only.
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research areas
- Stimulates growth hormone secretion
- Increases appetite and food intake
- May improve muscle mass and body composition
- Potential cachexia and wasting syndrome treatment
- Oral bioavailability for convenient administration
- Ghrelin receptor agonist activity
Side effects
| Effect | How often | Severity |
|---|---|---|
| Increased appetite and food intakeExpected pharmacological effect; may be therapeutic in cachexia but problematic in obesity. Manage by monitoring caloric intake and food choices. | Common | Mild |
| Increased cortisol levelsGhrelin agonists may transiently elevate cortisol; monitor if using long-term. Baseline and periodic cortisol testing recommended. | Uncommon | Moderate |
| Nausea or gastrointestinal discomfortMay occur with oral administration. Take with food if GI upset develops; usually resolves with continued use. | Uncommon | Mild |
| HeadacheReported in some users; typically mild and self-resolving. Ensure adequate hydration. | Uncommon | Mild |
| Fluid retention and edemaGH secretagogues may increase water retention. Monitor weight and lower extremity swelling; discontinue if significant edema develops. | Rare | Moderate |
| Hyperglycemia or impaired glucose toleranceGH excess can antagonize insulin action. Monitor fasting glucose and HbA1c, especially in those with metabolic risk factors. | Rare | Moderate |
| Joint or muscle achesMay occur with rapid GH elevation. Usually mild and transient. | Rare | Mild |
| Carpal tunnel syndrome (chronic use)Long-term GH excess can cause carpal tunnel; monitor for wrist pain or paresthesias with extended use. | Rare | Moderate |
Dosing reference
Dose scale from the research
- Starting
- 5 mcg
- Typical
- 10 mcg
- Upper end
- 25 mcg
| Parameter | Value |
|---|---|
| Dose range | 5-25 mcg |
Frequency, timing and route are for members | |
Checked October 2026
Research disclaimer. Figures are drawn from published research literature and community logs. They are not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution guide
- Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
- Do not shake the vial vigorously; gentle swirling prevents peptide degradation
- Discard immediately if the solution appears cloudy, discolored, or contains visible particles
- Use within 30 days of reconstitution when stored at 2-8°C
- Do not freeze the reconstituted solution; freezing may denature the peptide
- Use the PeptideVolt reconstitution calculator for your exact concentration
Storage and stability
Store lyophilized peptide at -20°C. Refrigerate after reconstitution (2-8°C). Protect from light.
Molecular and pharmacological data
Tabimorelin is an oral ghrelin receptor agonist (mimetic) that binds to the growth hormone secretagogue receptor (GHSR-1a) on pituitary somatotroph cells and hypothalamic neurons. This activation stimulates the release of growth hormone and increases appetite signaling through central ghrelin pathways. The compound was designed to provide oral bioavailability for GH secretion and appetite stimulation, with potential applications in cachexia, wasting syndromes, and age-related GH decline.
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Recent research
All results on PubMedComprehensive insights into the formation of metabolites of the ghrelin mimetics capromorelin, macimorelin and tabimorelin as potential markers for doping control purposes.
Lange T, et al. / Biomedical chromatography : BMC / 2021
Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats.
Holm AM, et al. / European journal of endocrinology / 2004
A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate.
Zdravkovic M, et al. / European journal of clinical pharmacology / 2003
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research citations
4 sources
PubMed PMID: 16940181. Tabimorelin demonstrated oral bioavailability and GH secretagogue activity in preclinical studies
PubMed PMID: 17088318. Ghrelin mimetics including tabimorelin showed appetite stimulation and GH release in animal models
PubMed PMID: 18056697. Oral ghrelin receptor agonists evaluated for cachexia and wasting conditions
PubMed PMID: 19923857. Tabimorelin pharmacokinetics and GH secretion dose-response relationship
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Research use only. All content on this page is provided for informational and educational purposes related to scientific research. Tabimorelin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.