Anamorelin
Also known as: RC-1291, Anavex
An oral ghrelin receptor agonist approved in Japan for cancer cachexia. Stimulates appetite and increases lean body mass in wasting conditions.
Beginner Basics
Plain-English guide to Anamorelin
What it does
Anamorelin tells your body to increase appetite and helps preserve muscle mass during periods of severe weight loss or wasting. Researchers study it because it can help people eat more and maintain strength when their body is breaking down.
Typical dose
Researchers typically use 50 to 100 mg taken by mouth once per day, starting at the lower dose and adjusting based on how well it works and how the body responds.
When to inject
Take it by mouth before your first meal of the day for best results.
Storage
Keep the tablets or powder at room temperature in a dry place away from light. Once mixed or opened, use within the timeframe specified on the package.
First-timer tip
Start at 50 mg and give your body at least a week or two to adjust before considering a higher dose-this helps you notice whether it's actually working for you.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Intended therapeutic effect in cachexia; may cause weight gain if caloric intake exceeds expenditure in non-cachectic individuals.
Often transient and may diminish with continued use. Taking with food may reduce incidence.
Reported in clinical trials; typically mild and self-resolving.
May occur early in treatment; advise caution with position changes.
Ghrelin agonism may transiently increase cortisol; monitor in patients with adrenal or metabolic concerns.
GH-mediated effects; typically mild and reversible upon discontinuation.
GH is diabetogenic; monitor blood glucose in patients with diabetes or prediabetes.
Related to increased appetite and food intake; usually resolves with dose adjustment.
Reported infrequently in clinical trials.
Ghrelin agonists may affect cardiac function; contraindicated in patients with uncontrolled arrhythmias or acute cardiac disease. Requires medical evaluation if occurs.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 50-100 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 389.52 |
| Half-life | 3-5 hours (oral) |
| Sequence | Members only |
Anamorelin is a selective ghrelin receptor (growth hormone secretagogue receptor 1a) agonist that mimics the action of endogenous ghrelin. It stimulates growth hormone release from the anterior pituitary and increases appetite signaling in the hypothalamus, leading to increased food intake and preservation of lean body mass in catabolic states such as cancer cachexia.
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