Semorelin

Mild erythema, swelling, or discomfort at injection site. Typically resolves within 1-2 hours. Minimize by rotating injection sites, allowing solution to reach room temperature, and using proper injection technique.

Transient facial flushing or warmth occurring 5-15 minutes after injection. Usually resolves within 30 minutes. More common with higher doses or rapid injection.

Mild to moderate headache occurring within 1-2 hours of injection. May be related to rapid GH elevation. Usually self-resolving; ensure adequate hydration.

Transient dizziness occurring shortly after injection. Sit or lie down if this occurs. Typically resolves within 15-30 minutes.

Mild nausea may occur within 1-2 hours of injection. Usually self-limiting. Avoid injecting immediately after large meals.

GH has counter-insulin effects; transient elevation in blood glucose may occur. Monitor blood glucose if diabetic or pre-diabetic. More likely with higher doses or in insulin-resistant individuals.

Mild arthralgias or myalgias may occur, particularly with higher doses. Usually resolves with continued use or dose reduction. May reflect increased anabolic activity.

Mild peripheral edema or fluid retention may develop with chronic use, particularly at higher doses. Monitor for weight gain and swelling. Usually mild and reversible.

Chronic GH elevation can increase risk of carpal tunnel syndrome. Symptoms include wrist pain, numbness, or tingling. Seek medical evaluation if symptoms develop.

GH can affect thyroid function; monitor TSH and free T4 periodically. More likely with pre-existing thyroid disease or iodine deficiency.

Long-term semorelin use may rarely result in antibody formation against the peptide, potentially reducing efficacy. Discontinuation usually results in antibody clearance.

Repeated injections at the same site can cause localized fat loss (lipoatrophy) or fat thickening (lipohypertrophy). Prevent by rotating injection sites systematically with each dose.