P21
Also known as: DTHFPIC Dipeptide
P21 is a nootropic peptide derived from CNTF (Ciliary Neurotrophic Factor). It promotes neurogenesis, especially in the hippocampus, and may improve learning and memory.
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in the first 1-2 weeks as the peptide crosses the blood-brain barrier. Usually resolves with continued use. Stay well-hydrated and consider taking in the morning with food.
Some users report initial fatigue as the brain adapts to increased neurogenic activity. Typically subsides within 2-3 weeks. Ensure adequate sleep and avoid driving if severely affected.
Redness, mild itching, or small bruising at the injection site. Prevent by rotating sites and using proper injection technique. Apply ice if needed.
Some users report improved mood or mild euphoria, likely due to increased hippocampal neurogenesis and BDNF signalling. This is generally considered a positive effect but should be monitored.
Increased neurogenesis and synaptic plasticity may enhance dream vividness or alter sleep architecture. Usually normalises after 2-4 weeks. Maintain consistent sleep hygiene.
Rare reports in early dosing phase. Sit or lie down if experienced. Ensure adequate hydration and food intake before injection.
Signs include rash, swelling of face/throat, difficulty breathing, or severe itching. Seek immediate medical attention. Discontinue use and inform healthcare provider of peptide use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 10-20 mg |
| Frequency | Daily |
| Timing | Morning |
| Route | Subcutaneous, Intranasal |
Effects build over time. Take for 4-8 weeks for optimal results.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
P21 is a synthetic peptide derived from Ciliary Neurotrophic Factor (CNTF) that crosses the blood-brain barrier and promotes neurogenesis, particularly in the hippocampus — the brain region critical for learning and memory formation. It activates neurotrophic signalling pathways that support the survival, growth, and differentiation of neurons, potentially enhancing synaptic plasticity and cognitive function over time.
CNTF Receptor Signalling
P21 mimics CNTF by binding to CNTF receptors on neural cells, activating the JAK-STAT and PI3K/Akt pathways, which promote neuronal survival and growth factor expression
Hippocampal Neurogenesis
Stimulates proliferation and differentiation of neural progenitor cells in the dentate gyrus of the hippocampus, increasing the number of functional neurons available for memory encoding
Synaptic Plasticity
Enhances long-term potentiation (LTP) and long-term depression (LTD) through increased BDNF expression and improved synaptic transmission, supporting learning and memory consolidation
- P21 is a CNTF-derived peptide that crosses the blood-brain barrier, allowing direct access to neural tissue
- Neurogenesis effects are most pronounced in the hippocampus, the primary brain region for declarative memory
- Cognitive benefits typically require 4-8 weeks of consistent dosing as new neurons integrate into existing circuits
- Animal models show improved performance on spatial learning and memory retention tasks
- Effects are thought to be mediated by increased neurotrophic factor signalling and reduced neuroinflammation
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. P21 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.