Melanotan II
Also known as: MT-II, MT-2
Melanotan II is a synthetic analog of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It stimulates melanogenesis, leading to skin tanning without UV exposure. It also has effects on libido and appetite.
Beginner Basics
Plain-English guide to Melanotan II
What it does
Melanotan II is a synthetic chemical that signals your body to produce more melanin (the pigment that makes skin darker), resulting in a tan without sun exposure. Researchers also study it for its effects on appetite and sexual function.
Typical dose
Researchers typically start with 250-500 micrograms injected under the skin daily until the desired tan develops, then reduce to 2-3 times per week for maintenance.
When to inject
Evening injections are commonly recommended because the peptide can cause nausea when first used, which may be easier to manage while resting.
Storage
Keep the dry powder in the refrigerator. Once you mix it with water, store it in the refrigerator and use it within a few weeks.
First-timer tip
Start with the lower dose and inject in the evening so any initial nausea won't disrupt your day-most people find side effects decrease after the first few doses.
On This Page
Research Status
Research compound - not FDA approved
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Most common during the first 3-7 days of use or with higher doses. Typically resolves with continued use (tachyphylaxis). Injecting in the evening and taking with food may reduce severity. Antiemetics (e.g., ondansetron) can be used if severe.
Transient redness and warmth of the face, often occurring 30-60 minutes after injection. Usually resolves within 1-2 hours. More pronounced with higher doses or rapid dose escalation.
Reported by many users, particularly males. This is a direct effect of melanocortin receptor activation in sexual function centers. Not considered adverse by most users but should be noted for informed consent.
Many users report reduced appetite and modest weight loss. This is mediated by MC4R activation in the hypothalamus. Ensure adequate caloric and nutrient intake, especially if using for extended periods.
Pre-existing pigmented lesions darken along with normal skin. This is expected and typically reverses after discontinuation. Users with numerous or atypical moles should consult a dermatologist before use.
Mild to moderate headaches reported in some users, typically early in treatment. Usually self-resolving. Ensure adequate hydration.
May occur shortly after injection, particularly with rapid dose escalation. Sit or lie down if this occurs. Usually resolves within 30 minutes.
Reported primarily in male users, especially at higher doses. Related to melanocortin receptor activation in sexual function pathways. May be unwanted in certain contexts.
Localized erythema, itching, or mild pain at the injection site. Usually mild and self-resolving. Proper injection technique and site rotation minimize risk.
Darkening of sensitive areas due to high melanocyte density. Typically reversible after discontinuation but may take weeks to months.
More severe nausea with actual vomiting occurs in a subset of users, particularly with rapid dose escalation or higher doses. Slow titration and evening dosing reduce risk. Antiemetics may be necessary.
Melanocortin receptors regulate vascular tone; some users report elevated blood pressure. Monitor blood pressure regularly, especially if using higher doses or for extended periods. Discontinue if significant elevation occurs.
Theoretical risk due to melanocyte stimulation and potential for malignant transformation in susceptible individuals. Users with personal or family history of melanoma, atypical moles, or xeroderma pigmentosum should avoid use. Regular dermatological monitoring is essential for all users.
Melanotan II is not approved for human use, and long-term safety data in humans are limited. Melanocyte stimulation theoretically increases melanoma risk, particularly in genetically predisposed individuals. This remains a major safety concern. Users must understand this risk and undergo regular dermatological screening.
Anaphylaxis or severe allergic reactions are rare but possible. Symptoms include difficulty breathing, swelling of face/throat, severe rash, or rapid heartbeat. Seek emergency medical attention immediately if these occur.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 250-500 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1645.9 g/mol |
| Half-life | Approximately 1-2 hours (plasma); tissue retention may extend effects |
| Sequence | Members only |
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that binds to melanocortin-1 receptors (MC1R) on melanocytes, stimulating the production and release of melanin. This leads to skin darkening (tanning) without UV exposure. The peptide also activates melanocortin receptors in other tissues, producing secondary effects on sexual function and appetite regulation.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Melanotan II is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.