Lenomorelin
Also known as: RC-1291, Ghrelin mimetic
Synthetic form of the native ghrelin peptide. A potent appetite stimulant that regulates energy balance and stimulates growth hormone release. Research compound for metabolic studies.
Beginner Basics
Plain-English guide to Lenomorelin
What it does
Lenomorelin mimics a natural hunger hormone in your body. Researchers study it because it signals your body to release growth hormone and increase appetite, which may help with energy and muscle maintenance.
Typical dose
Researchers typically use 1-5 micrograms per kilogram of body weight, injected under the skin. The exact dose depends on the specific research protocol being followed.
When to inject
Most research uses it in the morning or before meals, though timing can vary by protocol. Inject it consistently at the same time each day.
Storage
Keep the dry powder in a freezer at -20°C until you mix it. Once mixed with liquid, store it in a regular refrigerator between 2-8°C and keep it away from direct light.
First-timer tip
Start at the lower end of the dose range (1 mcg/kg) and only increase if needed, since this peptide can cause strong appetite effects that some find uncomfortable at higher doses.
On This Page
Research Status
Preclinical/Research Phase
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Expected pharmacological effect of ghrelin agonism. Occurs within 30–60 minutes of administration. Typically resolves as the peptide is metabolized.
Ghrelin signaling can transiently elevate cortisol levels. Effect is usually mild and self-resolving. Monitor in protocols involving stress-sensitive endpoints.
May occur due to sympathomimetic effects of ghrelin signaling. Typically mild and transient. Monitor vital signs in research protocols.
Reported in some research subjects. Usually resolves within 15–30 minutes. Related to vasodilatory effects of ghrelin.
Localized erythema, swelling, or mild discomfort at the injection site. Minimize by rotating injection sites and using proper aseptic technique. Usually resolves within 24 hours.
Reported in some research protocols. Typically mild and transient. May be related to changes in intracranial pressure or metabolic effects.
Uncommon but reported in some subjects. Usually mild and self-resolving. May be related to rapid changes in appetite signaling.
Localized fat loss or thickening can occur with repeated injections at the same site. Prevent by rotating injection sites systematically and spacing injections at least 1 inch apart.
Ghrelin can transiently increase blood glucose in some individuals. Monitor glucose levels in research protocols, especially in subjects with metabolic dysfunction. Effect is usually mild and reversible.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 1-5 mcg/kg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Lenomorelin (RC-1291) is a synthetic ghrelin receptor agonist that mimics the action of native ghrelin, a hormone produced primarily in the stomach. It binds to the growth hormone secretagogue receptor (GHSR-1a) on the hypothalamus and anterior pituitary, triggering the release of growth hormone and stimulating appetite through central nervous system pathways. The peptide also enhances gastric motility and regulates energy homeostasis by modulating metabolic rate and nutrient utilization.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Lenomorelin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.