KPV
Also known as: Lysine-Proline-Valine, α-MSH(11-13)
KPV is a C-terminal tripeptide of α-MSH with potent anti-inflammatory effects. It is being researched for inflammatory bowel disease and various inflammatory conditions.
Beginner Basics
Plain-English guide to KPV
What it does
KPV is a small protein fragment that researchers use to calm down the immune system and reduce inflammation, especially in the gut. It's commonly studied for helping people with inflammatory bowel conditions by reducing swelling and supporting healing.
Typical dose
Researchers typically use 500-1000 micrograms once or twice daily, either taken by mouth or injected under the skin depending on what they're studying.
When to inject
You can use it with or without food. If taking it orally for gut issues, there's no specific time requirement; if injecting, many prefer morning or evening for consistency.
Storage
Keep the dry powder in the refrigerator before mixing. After you mix it with liquid, store it in the fridge and use it within the timeframe indicated on your product.
First-timer tip
Start with the lower end of the dose range (500 mcg) for your first week to see how your body responds, then adjust upward if needed.
On This Page
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild erythema, itching, or transient swelling at the injection site. Usually resolves within 1-2 hours. Minimize by rotating sites, allowing solution to reach room temperature, and using proper injection technique. Apply ice if needed.
Transient facial flushing or warmth may occur within minutes of injection, likely due to melanocortin receptor activation on vascular endothelium. Resolves spontaneously within 10-30 minutes.
Mild nausea has been reported in some users, particularly with initial doses. Taking with food or reducing dose frequency may help. Usually diminishes with continued use.
Some users report mild appetite reduction, consistent with melanocortin pathway activation. This is typically mild and transient.
Occasional mild headache reported. Ensure adequate hydration and consider timing of injection relative to other activities.
Theoretical risk due to melanocortin receptor activation on melanocytes; not well-documented in clinical use of KPV at research doses. Monitor for changes in skin pigmentation with prolonged use.
Anaphylaxis or severe allergic reaction is extremely rare but possible in individuals with peptide sensitivity. Symptoms include difficulty breathing, throat tightness, severe rash, or swelling. Seek immediate medical attention if these occur. Have an epinephrine auto-injector available if you have a history of peptide allergies.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 500-1000 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 345.4 g/mol |
| Half-life | Approximately 15-30 minutes (subcutaneous); longer when administered orally due to intestinal absorption kinetics |
| Sequence | Members only |
KPV is a tripeptide derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH). It exerts potent anti-inflammatory effects primarily through activation of melanocortin receptors (particularly MC3R and MC4R) on immune cells, which suppresses pro-inflammatory cytokine production and promotes regulatory T cell differentiation. This mechanism makes it particularly relevant for conditions characterized by excessive intestinal inflammation, such as inflammatory bowel disease.
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Recent Research
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. KPV is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.