GHRP-5
Experimental growth hormone releasing peptide (GHRP) with limited clinical data. Research compound used to investigate growth hormone secretion pathways and metabolic effects. Not approved for human use.
Beginner Basics
Plain-English guide to GHRP-5
What it does
GHRP-5 signals your body to release more growth hormone, a natural substance involved in muscle growth and metabolism. Researchers study it to understand how growth hormone pathways work and its effects on body composition.
Typical dose
Researchers typically use 100-200 micrograms (mcg) injected under the skin once to three times daily, starting at the lower end to see how your body responds.
When to inject
Best used before meals or before bed, as timing around food may affect how well it works to trigger growth hormone release.
Storage
Keep the dry powder in a cool, dark place until mixed. Once mixed with liquid, store in the refrigerator and use within the timeframe specified by your supplier.
First-timer tip
Start with the lowest dose (100 mcg) for a few days to see how your body responds before increasing, and keep your injection timing consistent each day for best results.
On This Page
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Ghrelin receptor agonism stimulates appetite. Typically resolves within hours post-injection. Manage by planning meals in advance or eating before injection if appetite stimulation is undesirable.
Local inflammatory response at injection site. Usually resolves within 1-2 hours. Minimize by rotating sites, using proper injection technique, and allowing the solution to reach room temperature before injection.
Transient vasodilation associated with GH release. Typically occurs 15-30 minutes post-injection and resolves within 30-60 minutes.
May occur in response to rapid GH elevation. Usually mild and self-resolving. Ensure adequate hydration.
May occur with rapid GH secretion, particularly if injected while standing. Sit or lie down for 5-10 minutes post-injection if this occurs.
Transient increase in heart rate associated with GH release. Usually resolves within 30-60 minutes. Monitor if you have cardiovascular concerns.
Repeated GHRP dosing within 2-4 hours causes receptor desensitization and blunted GH response. Spacing doses 4-6+ hours apart or using intermittent dosing protocols (e.g., 5 days on, 2 days off) may help maintain responsiveness.
Chronic repeated injections at the same site can cause localized fat atrophy or hypertrophy. Prevent by strictly rotating injection sites with each dose and spacing injections at least 1 inch apart.
GHRPs may transiently elevate cortisol. Individuals with adrenal insufficiency or cortisol sensitivity should exercise caution. Not typically clinically significant with short-term use.
Some GHRPs may cause mild transient prolactin elevation. Clinically significant elevation is rare. Monitor if you have prolactin-sensitive conditions.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 100-200 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
GHRP-5 is a synthetic growth hormone releasing peptide that acts as a ghrelin receptor agonist (GHS-R1a), stimulating the release of growth hormone from the anterior pituitary gland. It works synergistically with endogenous growth hormone-releasing hormone (GHRH) to enhance GH secretion. The peptide mimics the action of ghrelin, a natural orexigenic hormone, triggering GH pulses independent of somatostatin inhibition.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. GHRP-5 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.