Cholecystokinin (CCK)
Also known as: CCK-8, CCK-33, Cholecystokinin octapeptide
A satiety hormone that promotes fullness and reduces food intake by signaling through CCK receptors. Researched for appetite regulation and metabolic health.
On This Page
Research Status
Clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Occurs in some subjects, particularly at higher doses or when injected on an empty stomach. Usually resolves within 30-60 minutes. May be reduced by injecting with or shortly after food.
Related to enhanced gastric and pancreatic secretion. Typically mild and self-resolving. More common with higher doses.
May occur due to increased pancreatic enzyme secretion and altered intestinal motility. Usually transient.
Reported in some research subjects. Mechanism unclear; may be related to systemic effects of CCK.
Mild erythema, itching, or swelling at injection site. Minimize by rotating sites and using proper injection technique.
Reported rarely in research settings. CCK has been studied in anxiety models; mechanism in humans unclear.
Extremely rare but documented in animal models at very high doses. Seek immediate medical attention if severe abdominal pain, elevated amylase, or lipase occurs.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.5-2 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1143 Da (CCK-8); 3918 Da (CCK-33) |
| Half-life | 2-3 minutes (endogenous CCK in circulation) |
| Sequence | Members only |
Cholecystokinin (CCK) is a gastrointestinal hormone that acts as a satiety signal by binding to CCK receptors (primarily CCKA and CCKB) on vagal afferent neurons and in the brain. This receptor activation triggers signals that promote feelings of fullness, reduce food intake, and regulate digestive processes including gallbladder contraction and pancreatic enzyme secretion. CCK's appetite-suppressing effects have been extensively studied as a potential mechanism for weight management and metabolic regulation.
Track your Cholecystokinin (CCK) research
Free account. No credit card required.
Recent Research
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
Proteomic Insights into the Effects of Jianweixiaoshi Tablets on Functional Dyspepsia with Spleen Deficiency in Rats.
Rikkunshito improves anorexia through ghrelin- and orexin-dependent activation of the brain hypothalamus and mesolimbic dopaminergic pathway in rats.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Browse the Research Library
40+ peptide profiles with mechanism summaries, dosing data, and reconstitution guides.
View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Cholecystokinin (CCK) is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.