Adipotide
Also known as: FTPP, Prohibitin-TP01
An experimental peptidomimetic that targets and destroys fat tissue blood supply through a targeted proapoptotic peptide. Causes fat cell death by cutting off blood supply to adipose tissue.
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Documented in preclinical studies at therapeutic doses. Manifests as elevated serum creatinine and blood urea nitrogen. Mechanism may involve vascular disruption in renal tissue or direct endothelial toxicity. Requires immediate medical evaluation and discontinuation.
Elevated liver enzymes (ALT, AST) observed in animal studies. Potential mechanism involves off-target vascular effects in hepatic tissue. Requires liver function monitoring and medical evaluation.
Local erythema, induration, or mild pain at injection site. Typically resolves within 24-48 hours. Rotate injection sites to minimize recurrence.
May occur due to rapid metabolic changes or systemic effects. Usually mild and self-resolving.
Reported in some preclinical studies. Typically mild and transient.
Potential for off-target vascular effects in tissues other than adipose tissue. Risk of thrombosis, hemorrhage, or ischemic injury to vital organs. Requires immediate medical attention.
Vascular disruption may trigger abnormal clotting. Requires hematologic monitoring and medical evaluation.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.5-1 mg |
| Frequency | 1x daily |
| Route | Subcutaneous |
Research compound in experimental stage. Animal studies only. Significant safety concerns documented. Not approved for human use. Dosing based on preclinical rodent models; human equivalent dosing unknown.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Adipotide is a peptidomimetic that targets the vasculature of adipose tissue through a proapoptotic mechanism. The peptide binds to integrin receptors on endothelial cells within fat tissue blood vessels, triggering apoptosis (programmed cell death) of these vascular cells. This vascular disruption cuts off blood supply to adipocytes, leading to selective fat cell death and reduction of adipose tissue mass.
Integrin-Mediated Apoptosis
Adipotide contains an RGD (arginine-glycine-aspartate) motif that binds to integrin receptors (αvβ3 and αvβ5) on endothelial cells. This binding triggers caspase-dependent apoptotic signaling, leading to programmed cell death of vascular endothelial cells.
Vascular Disruption
Destruction of the endothelial cell layer in adipose tissue vasculature leads to loss of blood perfusion to fat tissue, creating an ischemic environment that results in secondary adipocyte death.
Selective Adipose Targeting
The peptide preferentially targets integrin-expressing endothelial cells in adipose tissue vasculature, with minimal effects on vasculature in other tissues, providing some degree of tissue selectivity.
- Adipotide works through vascular disruption rather than direct adipocyte targeting
- The RGD integrin-binding motif is critical to its mechanism of action
- Preclinical studies showed rapid and significant fat loss in rodent models
- The peptide demonstrates preferential targeting of adipose tissue vasculature over other tissues
- Mechanism involves both acute vascular destruction and secondary adipocyte apoptosis
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