5-Amino-1MQ
Also known as: 1MQ, 5-Amino-1-methylquinolinium
NNMT (nicotinamide N-methyltransferase) inhibitor that promotes fat loss by increasing NAD+ levels and enhancing cellular energy metabolism.
Research Status
Early Research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Often occurs when taken on an empty stomach. Mitigate by taking with food. Usually resolves within 1-2 weeks as tolerance develops.
May occur during initial dosing. Ensure adequate hydration and consider dose reduction if persistent.
Possible due to increased metabolic rate and NAD+ activation. Avoid dosing in late afternoon or evening; take morning dose only.
May occur due to elevated metabolic rate. Monitor heart rate; discontinue and seek medical evaluation if severe or persistent.
May indicate dehydration or blood pressure changes. Ensure adequate fluid intake and monitor blood pressure.
Expected effect related to metabolic enhancement. Ensure adequate caloric and nutrient intake to support health.
Reported in preclinical studies at high doses. Monitor liver function if using for extended periods; discontinue if enzymes become significantly elevated.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 50-100 mg |
| Frequency | 1-2x daily |
| Timing | Morning or split AM/PM with food |
| Route | Oral |
Research compound with limited human clinical data. Start at 50 mg once daily and assess tolerance before increasing. Oral administration. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
5-Amino-1MQ inhibits NNMT, an enzyme that consumes NAD+ cofactors. By blocking NNMT activity, the compound increases intracellular NAD+ availability, which activates sirtuins and enhances mitochondrial function. This leads to increased energy expenditure, improved fat oxidation, and metabolic rate elevation.
NAD+ Salvage Pathway
NNMT inhibition prevents NAD+ depletion, allowing NAD+-dependent enzymes (sirtuins, PARPs) to remain active and support cellular energy metabolism and mitochondrial biogenesis.
Sirtuin Activation
Elevated NAD+ levels activate sirtuins (SIRT1, SIRT3), which regulate metabolic rate, mitochondrial function, and fat oxidation pathways.
Mitochondrial Biogenesis
NAD+-dependent signaling promotes PGC-1α activation and mitochondrial proliferation, increasing cellular energy production capacity.
- NNMT is highly expressed in adipose tissue and liver; inhibition shifts metabolism toward fat oxidation
- NAD+ is a critical cofactor for metabolic enzymes; increasing its availability enhances energy expenditure
- Sirtuin activation via NAD+ elevation supports longevity pathways and metabolic health
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. 5-Amino-1MQ is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.