Vialox
Also known as: Pentapeptide-3
An anti-wrinkle peptide with muscle relaxation properties that reduces expression lines. A safe alternative to injectable treatments for smoother skin texture.
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive skin types or with initial use. Typically resolves within 24-48 hours. Reduce application frequency to once daily if irritation persists. Perform a patch test before full facial application.
Can occur if used without adequate moisturizer. Always follow with a hydrating moisturizer. Ensure skin is not over-treated with other active ingredients.
Possible in individuals with sensitivity to peptides or formulation excipients. Discontinue use immediately if rash, swelling, or itching develops. Seek medical evaluation if symptoms persist beyond 48 hours.
Some peptide formulations may increase sun sensitivity. Always use SPF 30+ sunscreen during daytime use. Avoid prolonged sun exposure during treatment.
May occur immediately after application, particularly on sensitive areas around the eyes. Typically subsides within 5-10 minutes. If persistent, discontinue use and consult a dermatologist.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 3-5 % |
| Frequency | 1-2x daily |
| Timing | Morning and/or evening skincare routine |
| Route | Topical |
Topical application only. Use 2-3 drops or pea-sized amount per application. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Vialox is a topical peptide that mimics the action of acetyl hexapeptide-3 (Argireline), functioning as a SNARE complex inhibitor to reduce muscle contractions that cause expression lines. By limiting repetitive facial muscle movements, it smooths wrinkles and prevents new line formation. Additionally, it stimulates collagen and elastin synthesis in the dermis, improving skin texture, elasticity, and overall firmness through fibroblast activation.
SNARE Complex Inhibition
Vialox blocks the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, which mediates acetylcholine release at the neuromuscular junction. By reducing acetylcholine signaling, facial muscle contractions decrease, reducing the formation and deepening of expression lines — particularly on the forehead, between eyebrows, and around the eyes.
Collagen and Elastin Synthesis
The peptide stimulates fibroblast activity in the dermis, upregulating the production of type I and III collagen and elastin. This increases skin firmness, elasticity, and hydration, improving overall skin texture and reducing the appearance of fine lines through structural support rather than muscle relaxation alone.
Hyaluronic Acid Binding
Vialox enhances skin hydration by promoting hyaluronic acid retention in the stratum corneum and dermis. Improved hydration plumps the skin, reducing the visibility of fine lines and creating a smoother, more youthful appearance.
- Vialox works topically without systemic absorption, making it a safer alternative to injectable botulinum toxin
- Results develop gradually over 4-8 weeks of consistent use as collagen remodeling occurs
- The peptide is stable in topical formulations when stored at 2-8°C and protected from light
- Efficacy is enhanced when combined with other anti-aging ingredients such as retinol, vitamin C, or hyaluronic acid
- Unlike injectables, topical peptides do not cause muscle paralysis — they reduce muscle activity while maintaining natural facial expression
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Vialox is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.