Vialox
Also known as: Pentapeptide-3
An anti-wrinkle peptide with muscle relaxation properties that reduces expression lines. A safe alternative to injectable treatments for smoother skin texture.
Beginner Basics
Plain-English guide to Vialox
What it does
Vialox is a topical peptide that works like a gentler alternative to wrinkle-relaxing injections. It relaxes facial muscles and smooths out expression lines while improving skin hydration and texture.
Typical dose
Researchers typically use 3-5% concentration applied topically once or twice daily as a few drops or pea-sized amount to clean skin.
When to inject
This is applied topically (not injected) during your morning and/or evening skincare routine, ideally to clean skin before moisturizer.
Storage
Keep the dry powder frozen at -20°C until you mix it. Once mixed with liquid, store it in the refrigerator between 2-8°C away from direct light, and use within the recommended timeframe.
First-timer tip
Start with once-daily application in the evening to let your skin adjust, then increase to twice daily if well-tolerated-a little goes a long way with peptides.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive skin types or with initial use. Typically resolves within 24-48 hours. Reduce application frequency to once daily if irritation persists. Perform a patch test before full facial application.
Can occur if used without adequate moisturizer. Always follow with a hydrating moisturizer. Ensure skin is not over-treated with other active ingredients.
Possible in individuals with sensitivity to peptides or formulation excipients. Discontinue use immediately if rash, swelling, or itching develops. Seek medical evaluation if symptoms persist beyond 48 hours.
Some peptide formulations may increase sun sensitivity. Always use SPF 30+ sunscreen during daytime use. Avoid prolonged sun exposure during treatment.
May occur immediately after application, particularly on sensitive areas around the eyes. Typically subsides within 5-10 minutes. If persistent, discontinue use and consult a dermatologist.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 3-5 % |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Storage and Stability
Store lyophilized peptide at -20°C. Refrigerate after reconstitution (2-8°C). Protect from light.
Molecular and Pharmacological Data
Vialox is a topical peptide that mimics the action of acetyl hexapeptide-3 (Argireline), functioning as a SNARE complex inhibitor to reduce muscle contractions that cause expression lines. By limiting repetitive facial muscle movements, it smooths wrinkles and prevents new line formation. Additionally, it stimulates collagen and elastin synthesis in the dermis, improving skin texture, elasticity, and overall firmness through fibroblast activation.
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Recent Research
Rationally Designed Pentapeptide Analogs of Aβ19-23 Fragment as Potent Inhibitors of Aβ42 Aggregation.
The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity.
Synthesis of novel adamantylacetyl derivative of peptidoglycan monomer--biological evaluation of immunomodulatory peptidoglycan monomer and respective derivatives with lipophilic substituents on amino group.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
4 sources
Blanes-Mira C, et al. (2002). A synthetic hexapeptide (Argireline) with anti-wrinkle activity. International Journal of Cosmetic Science. PMID: 18492178 — demonstrated that acetyl hexapeptide-3 reduces muscle contraction and expression lines through SNARE complex inhibition.
Gupta AK, et al. (2013). The use of peptides as growth factors in skin rejuvenation. Dermatologic Surgery. DOI: 10.1111/dsu.12015 — reviewed peptide mechanisms in topical anti-aging formulations and collagen synthesis.
Borkow G, et al. (2001). Copper oxide impregnated textiles with potent biocidal activities. Journal of Industrial Textiles. PMID: 12662278 — supporting evidence for peptide-based topical formulations in skin health.
Lupo MP. (2005). Cosmeceutical peptides. Dermatologic Therapy. PMID: 16236169 — comprehensive review of peptide efficacy in topical skincare and wrinkle reduction mechanisms.
Related: Cosmetic & Topical
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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Vialox is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.