Leuphasyl
Also known as: Pentapeptide-18
Leuphasyl is a neurotransmitter-inhibiting peptide that reduces muscle contraction by mimicking enkephalins. It decreases acetylcholine secretion and is synergistic with Argireline for anti-wrinkle effects.
Beginner Basics
Plain-English guide to Leuphasyl
What it does
Leuphasyl is a topical peptide that relaxes facial muscles by reducing nerve signals, similar to how the body naturally calms muscle activity. Researchers use it to reduce wrinkles and expression lines, especially when combined with other anti-wrinkle peptides.
Typical dose
Applied at 2-5% concentration in skincare formulas; use the amount specified by your product instructions once or twice daily.
When to inject
Apply in the morning and evening to clean, dry skin. This is a topical product, not injected.
Storage
Keep the sealed container at room temperature away from direct sunlight. Once mixed into a product, follow the manufacturer's expiration date.
First-timer tip
Always apply to completely clean and dry skin for best absorption, and give it at least 2-3 weeks of consistent use before expecting visible results.
On This Page
Research Status
Cosmetic ingredient with safety testing
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in individuals with sensitive skin or those new to peptide-based cosmetics. Typically resolves within 24–48 hours. Discontinue use if irritation persists and perform a patch test before resuming.
Reported in isolated cases; likely due to localized neurotransmitter effects. Self-resolving and does not require intervention. Reduce application frequency if bothersome.
Possible in individuals with peptide sensitivities or allergies to other formulation ingredients. Discontinue immediately and consult a dermatologist if a rash, swelling, or severe itching develops.
May occur if the product is used without adequate moisturization. Ensure proper hydration with a compatible moisturizer, especially during initial use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-5% |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Leuphasyl is a synthetic peptide that mimics the structure and function of enkephalins, endogenous opioid neuropeptides. It inhibits acetylcholine release at the neuromuscular junction, reducing muscle contraction and facial expression lines. When applied topically, it works synergistically with other peptides like Argireline to diminish the appearance of wrinkles, particularly dynamic wrinkles caused by repeated muscle contractions.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Leuphasyl is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.