Syn-Coll
Also known as: Palmitoyl Tripeptide-5
Stimulates collagen synthesis by mimicking the body's own mechanism for triggering collagen production. Improves skin firmness, elasticity, and reduces fine lines.
Beginner Basics
Plain-English guide to Syn-Coll
What it does
This peptide tells your skin cells to make more collagen, which is the protein that keeps skin firm and elastic. Researchers use it to study how to reduce fine lines and improve skin texture.
Typical dose
Mixed into a cream or serum at 2-5% strength, applied once or twice daily to clean skin.
When to inject
Not injected-this is a topical cream or serum you apply during your morning and/or evening skincare routine.
Storage
Keep the dry powder in the freezer at -20°C. Once mixed into a liquid, store in the refrigerator between 2-8°C and keep it away from direct light.
First-timer tip
Start with the lower 2% concentration for a few weeks to let your skin adjust, then gradually increase to 5% if your skin tolerates it well.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive skin types during initial use. Typically resolves within 3-5 days. Reduce application frequency to 1x daily if irritation occurs.
Some users report mild sensations during or shortly after application. Usually subsides within 10-15 minutes. Does not indicate adverse reaction.
Possible in individuals with peptide sensitivity. Perform 24-hour patch test before full facial application. Discontinue use if rash, itching, or swelling develops.
May occur if used without adequate moisturizer. Ensure proper hydration with moisturizer applied after peptide absorption.
Some peptide formulations may increase sun sensitivity. Always use SPF 30+ sunscreen during daytime use.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-5 % |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Syn-Coll mimics endogenous collagen-stimulating signals to activate fibroblasts and increase Type I and III collagen production in the dermis. By triggering the body's natural collagen synthesis pathways, it improves skin structural integrity, firmness, and elasticity while reducing the appearance of fine lines and wrinkles.
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Recent Research
Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects.
Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels.
Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Syn-Coll is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.