Syn-Ake
Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate
Syn-Ake is a synthetic peptide mimicking snake venom that relaxes facial muscles and reduces wrinkle depth. It is a safe, topical alternative to Botox for smoothing expression lines.
Beginner Basics
Plain-English guide to Syn-Ake
What it does
Syn-Ake mimics a natural substance from snake venom that tells facial muscles to relax, which smooths out wrinkles and expression lines on the face. Researchers use it as a topical alternative to Botox injections.
Typical dose
Researchers typically use 2-4% concentration applied directly to clean skin once or twice daily.
When to inject
Apply in the morning and evening to clean, dry skin. No injection needed-this is a topical cream or serum you apply like regular skincare.
Storage
Keep the dry powder at room temperature in a cool, dark place. Once mixed into a product, follow the product's storage instructions (usually room temperature as well).
First-timer tip
Start with one application per day to see how your skin responds, then gradually move to twice daily if well-tolerated. This peptide is gentle enough for sensitive skin.
On This Page
Research Status
Cosmetic ingredient, extensively tested
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive individuals or with initial use. Typically resolves within 24–48 hours. Reduce application frequency to once daily if irritation persists.
Can occur if the product is used without adequate moisturiser. Always follow with a hydrating moisturiser, especially at night.
Possible in individuals with peptide sensitivity or allergy to formulation excipients. Perform a 24-hour patch test before full-face application. Discontinue and consult a dermatologist if a rash, swelling, or severe itching develops.
Some formulations may increase sun sensitivity. Always use SPF 30+ sunscreen during the day, especially when using Syn-Ake.
Extremely rare with topical application due to minimal systemic absorption. If experienced, discontinue use and consult a healthcare provider.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-4% |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 261.24 |
| Sequence | Members only |
Syn-Ake is a synthetic tripeptide (Gly-Asp-Leu) designed to mimic the neurotoxic mechanism of waglerin-1, a peptide found in temple viper venom. When applied topically, it binds to acetylcholine receptors at the neuromuscular junction and inhibits acetylcholine release, causing temporary relaxation of facial muscles responsible for expression wrinkles. This results in smoother skin and reduced wrinkle depth without systemic absorption or the permanence of surgical interventions.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Syn-Ake is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.