Syn-Ake
Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate
Syn-Ake is a synthetic peptide mimicking snake venom that relaxes facial muscles and reduces wrinkle depth. It is a safe, topical alternative to Botox for smoothing expression lines.
Research Status
Cosmetic ingredient, extensively tested
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive individuals or with initial use. Typically resolves within 24–48 hours. Reduce application frequency to once daily if irritation persists.
Can occur if the product is used without adequate moisturiser. Always follow with a hydrating moisturiser, especially at night.
Possible in individuals with peptide sensitivity or allergy to formulation excipients. Perform a 24-hour patch test before full-face application. Discontinue and consult a dermatologist if a rash, swelling, or severe itching develops.
Some formulations may increase sun sensitivity. Always use SPF 30+ sunscreen during the day, especially when using Syn-Ake.
Extremely rare with topical application due to minimal systemic absorption. If experienced, discontinue use and consult a healthcare provider.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-4% |
| Frequency | Daily topical |
| Timing | Morning and evening to clean skin |
| Route | Topical |
Snake venom mimic. Safe for regular use on sensitive skin.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 261.24 |
| Sequence | Gly-Asp-Leu (GDL) |
Syn-Ake is a synthetic tripeptide (Gly-Asp-Leu) designed to mimic the neurotoxic mechanism of waglerin-1, a peptide found in temple viper venom. When applied topically, it binds to acetylcholine receptors at the neuromuscular junction and inhibits acetylcholine release, causing temporary relaxation of facial muscles responsible for expression wrinkles. This results in smoother skin and reduced wrinkle depth without systemic absorption or the permanence of surgical interventions.
Neuromuscular Junction Inhibition
Syn-Ake mimics snake venom by blocking acetylcholine (ACh) release at the neuromuscular junction. This prevents muscle contraction in the facial muscles that create expression lines (forehead, glabella, crow's feet), leading to visible smoothing of wrinkles.
Topical Penetration & Skin Barrier Interaction
The peptide is formulated in cosmetic vehicles (serums, creams) that enhance skin penetration. It acts on superficial and mid-dermal muscle fibres without systemic absorption, making it a non-invasive alternative to botulinum toxin injections.
- Syn-Ake is a synthetic tripeptide that mimics the mechanism of action of waglerin-1, a neurotoxic peptide from temple viper venom
- It inhibits acetylcholine release at the neuromuscular junction, causing temporary muscle relaxation without permanent damage
- Topical application avoids systemic absorption and the risks associated with injectable neurotoxins
- Results are gradual (4–8 weeks) and fully reversible upon discontinuation
- Clinical studies show 30–45% reduction in wrinkle depth after 8–12 weeks of twice-daily application
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Syn-Ake is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.