Pentadecapeptide BPC 157
Also known as: BPC-157, Body Protection Compound-157
BPC-157 is a synthetic peptide derived from a protective protein found in gastric juice. It has remarkable healing properties for muscles, tendons, ligaments, and the gut.
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Usually resolves within 1-2 hours. Caused by local inflammation or histamine release. Minimise by rotating sites, using sterile technique, and allowing the solution to reach room temperature before injection. Apply ice if swelling persists.
More common when BPC-157 is used for gastrointestinal healing, as it may temporarily increase gut motility. Usually resolves within 30 minutes to 1 hour. Take with food if it occurs.
Possibly related to rapid vasodilation and improved blood flow. Sit or lie down if this occurs. Ensure adequate hydration and electrolyte intake.
May occur in the first few days of use, possibly due to increased blood flow or detoxification. Usually self-resolving. Stay hydrated and consider reducing dose temporarily if severe.
Some users report increased appetite due to improved gut function and nutrient absorption. Others report decreased appetite. Typically normalises within 1-2 weeks.
Reported anecdotally, possibly due to increased growth factor signalling or improved neurological function. Consider injecting in the morning rather than evening if this occurs.
True allergic reactions to BPC-157 are extremely rare but possible in individuals with peptide sensitivities. Seek immediate medical attention if difficulty breathing, severe swelling, or anaphylaxis occurs. Have an epinephrine auto-injector available if you have a history of peptide allergies.
Risk minimised by strict sterile technique, single-use needles, and proper site rotation. Signs include increasing redness, warmth, pus, or fever. Seek medical attention immediately if infection is suspected.
Caused by repeated injections at the same site. Prevent by rotating injection sites with every dose and maintaining at least 1 inch between injection points. Usually reversible if site rotation is implemented.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 250-500 mcg |
| Frequency | 1-2x daily |
| Timing | Morning and evening, or near injury site |
| Route | Subcutaneous, Intramuscular |
Can be injected near injury or systemically. Often stacked with TB-500.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1419 Da |
| Half-life | Approximately 6-8 hours (estimated from animal studies; human pharmacokinetics not fully characterised) |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
BPC-157 is a synthetic 15-amino acid peptide that enhances tissue repair and regeneration by upregulating growth factors (particularly VEGF and HGF), improving blood flow, and promoting angiogenesis. It acts on multiple signalling pathways involved in wound healing, collagen deposition, and cellular proliferation, making it effective for musculoskeletal injuries, tendon/ligament damage, and gastrointestinal healing.
Vascular Endothelial Growth Factor (VEGF) Signalling
BPC-157 upregulates VEGF expression, promoting new blood vessel formation (angiogenesis) and improving nutrient delivery to damaged tissues. Enhanced vascularisation accelerates healing of tendons, ligaments, and muscle.
Hepatocyte Growth Factor (HGF) Pathway
BPC-157 stimulates HGF production, which promotes cell proliferation, migration, and differentiation. HGF is critical for tissue regeneration and reduces inflammation in injured areas.
Nitric Oxide (NO) Signalling
BPC-157 enhances nitric oxide production, which improves vasodilation, blood flow, and reduces inflammation. NO also plays a role in collagen synthesis and tissue remodelling.
Fibroblast Activation and Collagen Deposition
BPC-157 promotes fibroblast proliferation and collagen type I and III synthesis, essential for structural integrity of tendons, ligaments, and skin.
Gut Barrier Function
BPC-157 strengthens the intestinal epithelial barrier by promoting tight junction protein expression and reducing intestinal permeability, supporting gastrointestinal healing and immune function.
- BPC-157 is derived from a protective peptide found naturally in gastric juice, making it structurally related to endogenous repair mechanisms
- It has been extensively studied in animal models for tendon, ligament, muscle, and gastrointestinal healing with consistent positive results
- BPC-157 appears to work synergistically with other healing peptides (e.g., TB-500) due to complementary mechanisms — TB-500 promotes cell migration while BPC-157 enhances growth factor signalling
- The peptide crosses the blood-brain barrier and may have neuroprotective effects, though this is less well-characterised in humans
- Clinical human trials are limited; most evidence comes from animal studies and anecdotal reports from athletes and biohackers
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Pentadecapeptide BPC 157 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.