Pancragen
Also known as: Pancreatic Bioregulator
Pancragen is a Khavinson bioregulator tetrapeptide that regulates insulin synthesis and supports pancreatic function. It may improve glucose metabolism and maintain pancreatic cell health.
Beginner Basics
Plain-English guide to Pancragen
What it does
Pancragen is a small protein fragment that helps your pancreas work better and supports how your body handles blood sugar. Researchers study it to see if it can help the pancreas produce insulin more effectively and keep pancreatic cells healthy.
Typical dose
Researchers typically use 10-20 mg taken by mouth once daily, usually for 10-20 days at a time.
When to inject
Take it with a meal. The cycle is typically 10-20 days on, then break for 3-6 months before repeating.
Storage
Keep the dry powder at room temperature in a cool, dry place away from light. Once mixed with liquid (if applicable), follow your supplier's instructions for how long it stays good.
First-timer tip
Start at the lower end of the dose range (10 mg) for your first cycle to see how your body responds, then adjust if needed in future cycles.
On This Page
Research Status
Khavinson bioregulator - Russian research
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur when taken on an empty stomach. Typically resolves by taking with food or after meals. Usually self-limiting and does not require discontinuation.
May occur in individuals with peptide sensitivity or shellfish allergy (some bioregulators are derived from marine sources). Discontinue immediately and seek medical attention if symptoms develop.
Theoretically possible if Pancragen enhances insulin secretion in individuals with existing insulin sensitivity or diabetes. Monitor blood glucose if taking concurrently with antidiabetic medications. Seek immediate medical attention if symptoms of hypoglycemia develop (tremor, sweating, confusion, loss of consciousness).
Occasionally reported in early use. Usually resolves within a few days as the body adjusts. Stay hydrated and consider over-the-counter analgesics if needed.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 10-20 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
Pancragen is a Khavinson bioregulator tetrapeptide that acts as a tissue-specific regulator of pancreatic function. It is proposed to enhance insulin synthesis and secretion by supporting the metabolic activity of pancreatic beta cells, thereby improving glucose homeostasis and maintaining pancreatic cell health. The mechanism is believed to involve selective stimulation of gene expression in pancreatic tissue, promoting cellular differentiation and metabolic optimization.
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Recent Research
[Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys].
[Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys].
Effects of pancragen on the differentiation of pancreatic cells during their ageing.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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