Palmitoyl Tetrapeptide-7
Also known as: Pal-GQPR, Palmitoyl Tetrapeptide-7 (Matrixyl 3000 component)
A synthetic tetrapeptide conjugated to palmitic acid (a 16-carbon fatty acid) that penetrates the skin barrier and reduces pro-inflammatory cytokine production, particularly interleukin-6 (IL-6). Commonly used as a component of Matrixyl 3000 formulations to improve skin elasticity, reduce fine lines, and support dermal matrix remodeling through fibroblast stimulation.
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in individuals with sensitive skin or when first introducing the product. Typically resolves within 1-2 days of continued use as skin acclimates. If irritation persists beyond 3-5 days, discontinue use and perform a patch test before reintroduction.
Some users report a mild tingling sensation during or immediately after application, particularly on the face. This is usually transient and resolves within minutes. If it persists or intensifies, rinse the area with cool water and reduce application frequency.
Rare but possible in individuals with known sensitivity to peptides or other formulation components. Symptoms include localized redness, swelling, itching, or hives. Discontinue use immediately and consult a dermatologist if symptoms develop. Always perform a 24-hour patch test before full facial application.
Improved skin barrier function and increased cell turnover may temporarily increase sun sensitivity. Always use broad-spectrum sunscreen (SPF 30+) during daytime use, especially when first introducing the product.
May occur if the product is used in combination with other active ingredients (retinoids, vitamin C, AHAs) or in very dry climates. Ensure adequate moisturization and reduce application frequency if dryness develops. Use a hydrating moisturizer after the peptide product has absorbed.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-5 % |
| Frequency | 1-2x daily |
| Timing | Morning and/or evening skincare routine |
| Route | Topical |
Topical application only. Concentration in commercial cosmetic formulations typically ranges from 2-5% by weight. Apply to clean, dry skin. For facial use, a pea-sized amount (approximately 0.5g) is sufficient per application. Avoid contact with eyes; if contact occurs, rinse thoroughly with water. Allow product to fully absorb before applying other skincare products.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | approximately 575 Da (tetrapeptide core) + 256 Da (palmitic acid) ≈ 831 Da total |
| Half-life | Not applicable — topical application; local tissue residence time is hours to days depending on formulation |
| Sequence | Palmitoyl-GQPR (Gly-Gln-Pro-Arg with N-terminal palmitic acid conjugation) |
Palmitoyl Tetrapeptide-7 is a synthetic tetrapeptide (GQPR) conjugated to palmitic acid, a 16-carbon saturated fatty acid that enhances skin penetration. The peptide reduces pro-inflammatory cytokine production, particularly interleukin-6 (IL-6), which is elevated in aging and damaged skin. By suppressing IL-6 signaling, it promotes fibroblast activity and increases synthesis of collagen types I and III, supporting dermal matrix remodeling and improving skin elasticity, firmness, and appearance of fine lines.
IL-6 Suppression and Anti-Inflammatory Signaling
Palmitoyl Tetrapeptide-7 inhibits IL-6 production in dermal fibroblasts and keratinocytes, reducing chronic skin inflammation associated with aging, UV damage, and environmental stress. This suppression of pro-inflammatory cytokines creates a microenvironment favorable for collagen synthesis and dermal remodeling.
Fibroblast Activation and Collagen Synthesis
By reducing IL-6-mediated inhibition of fibroblast function, the peptide stimulates increased production of procollagen I and III, the precursors to mature collagen. This leads to improved skin matrix density, elasticity, and structural integrity.
Skin Barrier Enhancement
Increased collagen and improved dermal matrix support the epidermal-dermal junction, enhancing skin barrier function and reducing transepidermal water loss (TEWL), which contributes to improved skin hydration and appearance.
- The palmitic acid conjugate enhances transdermal penetration, allowing the tetrapeptide to reach viable dermal layers
- IL-6 is a key driver of age-related skin inflammation and collagen degradation; suppressing it supports matrix preservation
- In vitro studies demonstrate 30-50% reduction in IL-6 secretion and increased procollagen synthesis at concentrations of 2-5%
- Effects are cumulative and require consistent daily application for 4-8 weeks to achieve visible clinical improvement
- Synergistic with other peptides (e.g., palmitoyl oligopeptide) in formulations like Matrixyl 3000 for enhanced efficacy
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Palmitoyl Tetrapeptide-7 is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.