Pal-GHK
Also known as: Palmitoyl tripeptide-1, Copper peptide GHK-Cu (palmitoylated form)
Palmitoylated copper peptide designed for topical skincare. Pal-GHK is a lipid-conjugated form of the copper tripeptide GHK, which enhances skin penetration and stability. Used in anti-aging formulations to stimulate collagen synthesis and reduce visible signs of aging.
Beginner Basics
Plain-English guide to Pal-GHK
What it does
This is a skin-care ingredient that helps your skin make more collagen (the protein that keeps skin firm and youthful) and reduces the appearance of wrinkles and fine lines. Researchers use it in anti-aging creams because it absorbs into skin better than regular collagen-boosting peptides.
Typical dose
Apply a product containing 2-5% concentration of this ingredient once or twice daily to clean, dry skin.
When to inject
This is not injected-it's applied topically as a cream or serum in your morning and/or evening skincare routine.
Storage
Keep the dry powder in a cool, dark, dry place away from moisture and sunlight. Once mixed into a product, follow the manufacturer's storage instructions, typically in a cool environment away from direct heat.
First-timer tip
Give it at least 4-12 weeks before deciding if it's working for you, and start with the lower 2% concentration to make sure your skin tolerates it well before moving up to 5%.
On This Page
Research Status
Limited Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
May occur in sensitive skin types or with initial use. Usually resolves within 1-2 weeks as skin acclimates. If persistent, reduce application frequency to once daily or discontinue use.
Some users report a mild tingling sensation immediately after application. This is typically transient and resolves within minutes. Not a sign of adverse reaction.
May occur in individuals with copper sensitivity or allergy to other formulation ingredients. Perform a patch test 24-48 hours before full application. If rash, swelling, or severe itching develops, discontinue immediately and consult a dermatologist.
May occur if applied to already-dry skin or if used without adequate moisturizer. Ensure skin is hydrated and follow with a compatible moisturizer.
No direct photosensitizing effect documented, but copper peptides may enhance skin cell turnover. Always use SPF 30+ sunscreen during daytime use to prevent UV-induced damage.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 2-5 % |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | approximately 571 Da (palmitoylated tripeptide) |
| Half-life | Not precisely defined for topical application; stability in formulation typically 6-12 months when stored properly |
| Sequence | Members only |
Pal-GHK is a lipid-conjugated form of the copper tripeptide GHK that enhances skin penetration and stability compared to unmodified GHK. The palmitoyl group (a 16-carbon fatty acid) increases the peptide's ability to cross the stratum corneum and remain active in the dermis. Once in the skin, Pal-GHK binds to copper and activates fibroblasts to increase collagen I, III, and IV synthesis, while simultaneously reducing matrix metalloproteinase (MMP) activity that degrades collagen. This dual mechanism—increased collagen production and decreased collagen breakdown—results in improved skin firmness, elasticity, and reduction of visible signs of aging.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Pal-GHK is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.