Epitalon
Also known as: Epithalon, Ala-Glu-Asp-Gly
A tetrapeptide that regulates telomerase activity and supports circadian rhythm restoration through pineal gland modulation.
Beginner Basics
Plain-English guide to Epitalon
What it does
Epitalon is a small protein chain that researchers study for its effects on cellular aging and sleep-wake cycles. It's commonly used in research to support the body's natural clock and promote better sleep patterns.
Typical dose
Researchers typically use 5-10 mg injected under the skin once daily. A common research protocol is 10 days of injections followed by a break period.
When to inject
Inject in the evening, 30-60 minutes before bed, to align with its sleep-supporting effects.
Storage
Keep the dry powder in a cool, dark place at room temperature. Once mixed with liquid, store in the refrigerator and use within 2-3 weeks.
First-timer tip
Start at the lower end of the dose range (5 mg) and give it a full 10-day cycle before deciding if it's working for you-researchers typically observe effects after consistent use.
On This Page
Research Status
Clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild redness, swelling, or bruising at the injection site. Usually resolves within 24-48 hours. Minimize by rotating sites and using proper injection technique.
Occasional mild headaches reported in early treatment. Typically transient and resolve within a few days. Ensure adequate hydration.
Some users report initial sleep changes or vivid dreams as circadian rhythms adjust. Usually normalizes within 1-2 weeks as the body adapts.
Occasional reports of transient fatigue during the first few days of a course. Typically self-resolving.
Severe allergic reactions are rare but possible. Seek immediate medical attention if you experience difficulty breathing, severe swelling, or anaphylaxis. Discontinue use and consult a healthcare provider.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 390 |
| Sequence | Members only |
Epitalon is a tetrapeptide (Ala-Glu-Asp-Gly) that modulates telomerase activity and supports circadian rhythm regulation through pineal gland signaling. It acts as a bioregulator that influences gene expression related to cellular aging, antioxidant defense, and neuroendocrine function. The peptide is believed to restore age-related declines in telomerase activity and enhance the body's natural circadian synchronization mechanisms.
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Recent Research
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Epitalon is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.