Epitalon
Also known as: Epithalon, Ala-Glu-Asp-Gly
A tetrapeptide that regulates telomerase activity and supports circadian rhythm restoration through pineal gland modulation.
Research Status
Clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Mild redness, swelling, or bruising at the injection site. Usually resolves within 24-48 hours. Minimize by rotating sites and using proper injection technique.
Occasional mild headaches reported in early treatment. Typically transient and resolve within a few days. Ensure adequate hydration.
Some users report initial sleep changes or vivid dreams as circadian rhythms adjust. Usually normalizes within 1-2 weeks as the body adapts.
Occasional reports of transient fatigue during the first few days of a course. Typically self-resolving.
Severe allergic reactions are rare but possible. Seek immediate medical attention if you experience difficulty breathing, severe swelling, or anaphylaxis. Discontinue use and consult a healthcare provider.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 5-10 mg |
| Frequency | 1x daily |
| Timing | Evening, 30-60 minutes before bed |
| Route | Subcutaneous |
Typical research protocols use 5-10mg per injection. Epitalon is often administered as a 10-day course followed by a break period. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline — use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 390 |
| Sequence | Ala-Glu-Asp-Gly |
Epitalon is a tetrapeptide (Ala-Glu-Asp-Gly) that modulates telomerase activity and supports circadian rhythm regulation through pineal gland signaling. It acts as a bioregulator that influences gene expression related to cellular aging, antioxidant defense, and neuroendocrine function. The peptide is believed to restore age-related declines in telomerase activity and enhance the body's natural circadian synchronization mechanisms.
Telomerase Activation
Epitalon may upregulate telomerase reverse transcriptase (TERT) expression, supporting telomere maintenance and cellular replicative capacity. This pathway is central to the peptide's proposed anti-aging mechanism.
Pineal Gland Modulation
The peptide influences pineal gland function, potentially enhancing melatonin synthesis and secretion. This supports circadian rhythm restoration and sleep-wake cycle regulation.
Antioxidant Defense
Epitalon may upregulate expression of endogenous antioxidant enzymes (SOD, catalase, glutathione peroxidase), reducing oxidative stress and supporting cellular protection.
Neuroendocrine Regulation
The peptide acts as a bioregulator of neuroendocrine function, influencing hormone synthesis and secretion patterns that decline with age.
- Epitalon is a synthetic tetrapeptide derived from the pineal gland bioregulator research of Vladimir Khavinson
- The peptide demonstrates telomerase-activating properties in cultured cells and animal models
- Circadian rhythm restoration is a primary mechanism, with evening administration supporting natural melatonin cycles
- Epitalon is classified as a Khavinson bioregulator — a class of short peptides designed to regulate organ-specific gene expression
- Clinical evidence in humans is limited; most data come from Russian research institutions and animal studies
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Epitalon is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.