Apigenin
A flavonoid with senolytic and anti-inflammatory properties used in cellular rejuvenation protocols alongside peptide therapies.
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Nausea, mild abdominal discomfort, or loose stools may occur, particularly on an empty stomach. Mitigate by taking with food containing fat. Usually resolves within 3-5 days as tolerance develops.
Occasional mild headache reported in early use. Ensure adequate hydration and take with meals. Typically self-resolving.
Rash, itching, or mild angioedema possible in individuals with flavonoid sensitivity. Discontinue immediately and seek medical attention if symptoms develop.
Apigenin inhibits cytochrome P450 3A4, potentially increasing plasma levels of medications metabolized by this enzyme (e.g., statins, immunosuppressants, certain antihistamines). Consult healthcare provider before use if taking prescription medications.
Rare reports of increased sun sensitivity. Use broad-spectrum sunscreen (SPF 30+) during extended sun exposure.
Occasional dizziness reported at higher doses. Reduce dose and ensure adequate hydration. Resolve by taking with food.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 200-500 mg |
| Frequency | 1-2x daily |
| Timing | With meals to enhance absorption |
| Route | Subcutaneous |
Apigenin is a flavonoid compound typically administered orally. Start at lower doses and titrate based on tolerance. For research purposes only.
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2–8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 270.24 g/mol |
| Half-life | 0.3-1.5 hours (oral); undergoes rapid hepatic metabolism and glucuronidation |
Apigenin is a plant-derived flavonoid that functions as a senolytic agent, selectively eliminating senescent (aged, dysfunctional) cells through induction of apoptosis and autophagy. It modulates multiple inflammatory pathways including NF-κB and MAPK signaling, reducing pro-inflammatory cytokine production. Additionally, apigenin enhances mitochondrial function and antioxidant defenses, supporting cellular rejuvenation when used alongside peptide therapies targeting growth factors and tissue repair.
Senolytic pathway (p53/p21 activation)
Apigenin induces selective apoptosis in senescent cells by activating p53-dependent pathways, leading to programmed cell death of dysfunctional cells while sparing healthy cells
NF-κB inhibition
Suppresses nuclear factor-kappa B signaling, reducing production of pro-inflammatory cytokines (TNF-α, IL-6, IL-8) that drive chronic inflammation and cellular aging
Mitochondrial autophagy (mitophagy)
Enhances clearance of damaged mitochondria through PINK1/Parkin-mediated autophagy, restoring cellular energy production and reducing oxidative stress
Antioxidant defense (SOD/catalase upregulation)
Increases expression of superoxide dismutase and catalase, enhancing the cell's intrinsic antioxidant capacity and reducing reactive oxygen species accumulation
- Apigenin selectively targets senescent cells while preserving healthy cell populations
- Low oral bioavailability (approximately 2-10%) is offset by its potent cellular effects at low concentrations
- Synergistic with peptide therapies that promote growth factor signaling and tissue repair
- Crosses the blood-brain barrier, supporting neuroinflammation reduction and cognitive health
- Metabolized via hepatic glucuronidation and sulfation; minimal systemic accumulation
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Apigenin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.