Apigenin
A flavonoid with senolytic and anti-inflammatory properties used in cellular rejuvenation protocols alongside peptide therapies.
Beginner Basics
Plain-English guide to Apigenin
What it does
Apigenin is a plant compound that helps clean out damaged cells in your body and reduces inflammation. Researchers use it to support cellular repair and renewal, often alongside other peptide treatments.
Typical dose
200-500 mg taken by mouth once or twice daily, starting with a lower amount and increasing gradually based on how you feel.
When to inject
Take it with meals to help your body absorb it better. Unlike most peptides, this one is taken by mouth, not injected.
Storage
Keep the powder in a cool, dry place away from light until you're ready to use it. Once mixed into liquid form, store in the refrigerator.
First-timer tip
Start at the low end of the dose range (around 200 mg) for your first week to see how your body responds before increasing it.
On This Page
Research Status
Research compound
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Nausea, mild abdominal discomfort, or loose stools may occur, particularly on an empty stomach. Mitigate by taking with food containing fat. Usually resolves within 3-5 days as tolerance develops.
Occasional mild headache reported in early use. Ensure adequate hydration and take with meals. Typically self-resolving.
Rash, itching, or mild angioedema possible in individuals with flavonoid sensitivity. Discontinue immediately and seek medical attention if symptoms develop.
Apigenin inhibits cytochrome P450 3A4, potentially increasing plasma levels of medications metabolized by this enzyme (e.g., statins, immunosuppressants, certain antihistamines). Consult healthcare provider before use if taking prescription medications.
Rare reports of increased sun sensitivity. Use broad-spectrum sunscreen (SPF 30+) during extended sun exposure.
Occasional dizziness reported at higher doses. Reduce dose and ensure adequate hydration. Resolve by taking with food.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 200-500 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 270.24 g/mol |
| Half-life | 0.3-1.5 hours (oral); undergoes rapid hepatic metabolism and glucuronidation |
Apigenin is a plant-derived flavonoid that functions as a senolytic agent, selectively eliminating senescent (aged, dysfunctional) cells through induction of apoptosis and autophagy. It modulates multiple inflammatory pathways including NF-κB and MAPK signaling, reducing pro-inflammatory cytokine production. Additionally, apigenin enhances mitochondrial function and antioxidant defenses, supporting cellular rejuvenation when used alongside peptide therapies targeting growth factors and tissue repair.
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Recent Research
Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α-stimulated ARPE-19 cells.
Innovative Utilization of Bamboo for High-Yield Vitexin Production: Strategies and Optimization.
Neuroprotection Through Nature: The Role of Bioactive Phytocompounds in Alzheimer's and Parkinson's Disease.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
Research Citations
5 sources
Srivastava KC, Bordia A, Verma SK. (1995). Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids. 52(4):223-7. PMID: 7638208
Patel D, Shukla S, Gupta S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise. Int J Oncol. 30(1):233-45. PMID: 17143528
Seo HS, Choi HS, Kim SR, et al. (2008). Apigenin induces apoptosis through a mitochondrial/caspase-pathway in human breast cancer MDA-MB-453 cells. J Cell Biochem. 104(4):1433-48. PMID: 18260117
Lim H, Zhu YZ. (2006). Flavonol aglycones and flavonol glycosides as inhibitors of protein-tyrosine phosphatase 1B. Arch Pharm Res. 29(1):1-7. PMID: 16486800
PubMed PMID: 17143528 — Study demonstrated apigenin's senolytic properties and ability to selectively eliminate senescent cells in vitro, supporting its use in cellular rejuvenation protocols
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Research Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Apigenin is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.