Alpha-MSH
Also known as: α-MSH, Alpha-Melanocyte Stimulating Hormone
Alpha-Melanocyte Stimulating Hormone, a tridecapeptide with potent anti-inflammatory, neuroprotective, and immunomodulatory properties. Binds melanocortin receptors (MC1R, MC3R, MC4R) to modulate immune responses, reduce pro-inflammatory cytokines, and support tissue repair. Also involved in pigmentation regulation and appetite signaling.
Beginner Basics
Plain-English guide to Alpha-MSH
What it does
This peptide helps calm your immune system's inflammatory responses and supports your body's natural repair processes. Researchers study it because it may reduce swelling-related chemicals in the body and help protect nerve tissue.
Typical dose
Researchers typically start with 0.1 mg once daily via a small injection under the skin, increasing to 0.25-0.5 mg based on how the body responds.
When to inject
Any time of day works, but pick the same time each day so you can track effects consistently.
Storage
Keep the dry powder in a cool, dark place at room temperature. Once mixed with liquid, store in the refrigerator and use within 2-4 weeks.
First-timer tip
Start at the lowest dose (0.1 mg) for your first week to see how your body responds before increasing-this is called titrating up and helps you find your best dose.
On This Page
Research Status
Moderate Clinical Data
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Occurs within minutes of injection, typically resolves within 15–30 minutes. Related to MC1R activation on cutaneous vasculature. Manage by injecting in the evening or before rest.
May occur with higher doses (>0.5 mg) or rapid dose escalation. Related to MC3R and MC4R activation in the hypothalamus and brainstem. Manage by reducing dose or taking with food.
MC4R activation in the hypothalamus can reduce appetite. Typically mild and transient. Clinically relevant only at higher doses.
MC1R activation on melanocytes increases melanin production. More pronounced in individuals with darker skin tones or significant sun exposure. Manage by using sunscreen (SPF 30+) and limiting UV exposure.
Local inflammatory response at injection site. Typically resolves within 24–48 hours. Manage by rotating injection sites and using proper aseptic technique.
Reported in some users, possibly related to rapid changes in systemic inflammation or hypothalamic signaling. Manage with hydration and over-the-counter analgesics if needed.
MC4R activation in the hypothalamus and spinal cord can enhance erectile function. Typically transient and self-resolving.
Possible in individuals with hypersensitivity to peptides or excipients. Seek immediate medical attention if difficulty breathing, throat swelling, or severe rash occurs. Have epinephrine available if history of peptide allergies.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.1-0.5 mg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | 1817.9 |
| Half-life | 10-20 minutes (in vivo); stability varies with formulation and storage conditions |
| Sequence | Members only |
Alpha-MSH is a tridecapeptide that activates melanocortin receptors (particularly MC1R, MC3R, and MC4R) on immune cells, neurons, and other tissues. This activation suppresses pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β), enhances regulatory T cell differentiation, and promotes anti-inflammatory signaling through cAMP-dependent pathways. The peptide also modulates hypothalamic appetite centers and supports tissue repair through neuroprotective mechanisms.
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Recent Research
Corrigendum to "MicroRNA-122-3p involved in an α-melanocyte stimulating hormone-stimulated melanogenesis by targeting tyrosinase" [Biochem. Biophys. Res. Commun. 809 (2026) 153501].
Constitutive activation of MC1R in the large-billed crow (Corvus macrorhynchos) and its potential role in black plumage.
Glabridin Inhibits Melanogenesis and Melanin Transfer via Wnt/β-Catenin Pathway and Rho Family GTPase-Mediated Dendritic Formation Suppression.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Alpha-MSH is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.