Natriuretic Peptides (BNP, ANP)
Also known as: B-type Natriuretic Peptide (BNP), Atrial Natriuretic Peptide (ANP), N-terminal pro-BNP (NT-proBNP), Nesiritide (recombinant BNP)
Endogenous peptides that regulate blood pressure, fluid balance, and cardiac function. Researched for heart failure and hypertension management.
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Research Status
Clinical trials
For research purposes only. Not approved for human use. Not medical advice.
Research Areas
Side Effects
Significant blood pressure reduction is the primary pharmacological effect. Requires continuous monitoring during IV infusion. May limit dose escalation. Symptomatic hypotension (dizziness, syncope) can occur.
Often related to hypotension. Usually resolves with dose adjustment or fluid management.
Paradoxical worsening of renal function has been reported in some heart failure patients, particularly with aggressive diuresis. Monitor serum creatinine and electrolytes closely.
Increased urinary potassium excretion can lead to low serum potassium. Monitor electrolytes and supplement as needed.
Excessive sodium excretion and water retention can lower serum sodium. More common with prolonged infusions.
Reflex tachycardia may occur in response to hypotension. Usually mild and self-limited.
Electrolyte abnormalities (hypokalemia, hyponatremia) can predispose to arrhythmias. Continuous cardiac monitoring is essential.
Hypersensitivity reactions including rash, angioedema, or anaphylaxis are rare but possible. Discontinue immediately if suspected.
Elevation in blood urea nitrogen may occur, particularly in volume-depleted patients. Monitor renal function parameters.
Dosing Reference
| Parameter | Value |
|---|---|
| Dose range | 0.01-0.1 mcg |
Frequency, timing and route - members only | |
Research disclaimer
Figures drawn from published research literature and community logs. Not clinical recommendations. Consult a qualified professional. Research use only.
Reconstitution Guide
Do not use saline or bacteriostatic saline, use only bacteriostatic water for reconstitution
Do not shake the vial vigorously; gentle swirling prevents peptide degradation
Discard immediately if the solution appears cloudy, discolored, or contains visible particles
Use within 30 days of reconstitution when stored at 2-8°C
Do not freeze the reconstituted solution; freezing may denature the peptide
Use the PeptideVolt reconstitution calculator for your exact concentration
Molecular and Pharmacological Data
| Molecular weight | ANP: 3,067 Da; BNP: 3,464 Da |
| Half-life | ANP: 2-3 minutes; BNP: 15-20 minutes |
| Sequence | Members only |
Natriuretic peptides (ANP and BNP) are endogenous hormones that bind to natriuretic peptide receptors (NPR-A and NPR-B) on vascular smooth muscle, endothelial cells, and renal tissue. This activation increases intracellular cyclic GMP, leading to vasodilation, reduced cardiac preload and afterload, increased sodium and water excretion, and inhibition of the renin-angiotensin-aldosterone system (RAAS). These coordinated effects lower blood pressure, reduce cardiac workload, and improve cardiac function in heart failure.
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Recent Research
Cardioprotective effects of platycodon grandiflorum granules in HER2-positive early breast cancer patients receiving trastuzumab plus pertuzumab: study protocol for a double blind randomized controlled trial.
Baseline B-Type Natriuretic Peptide and Clinical Outcomes Following Transcatheter Tricuspid Valve Replacement.
Association of elevated cyclic GMP levels with hemodynamic changes in HFrEF patients treated with sacubitril/valsartan and vericiguat: a pilot study.
Source: PubMed / NCBI. Updated daily. Articles are listed for research reference only.
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View all peptidesResearch Use Only. All content on this page is provided for informational and educational purposes related to scientific research. Natriuretic Peptides (BNP, ANP) is not approved for human use by the FDA or any equivalent regulatory body. This is not medical advice. Do not use any substance discussed here for therapeutic, diagnostic, or preventative purposes. Consult a qualified healthcare professional before making any health-related decisions. The Peptide Volt does not endorse the use of any research chemicals. 18+ only.